Pharmacodynamic Effects of a d-Amino Acid Oxidase Inhibitor Indicate a Spinal Site of Action in Rat Models of Neuropathic Pain
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...inhibitor, which increased D-serine concentrations in brain and plasma,reduced spontaneous neuronal activity in both central and peripheral recordings and alsoattenuated pain behaviors in rat models of neuropathic and inflammatory pain[34]....
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"Pharmacodynamic Effects of a d-Amin..." refers background in this paper
...DAAO also has been reported to be expressed in the spinal cord of rats (Kappor and Kapoor, 1997), with localization including the dorsal horn....
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"Pharmacodynamic Effects of a d-Amin..." refers background in this paper
...Increases in cerebellum D-serine concentrations have also been reported after cerebellar DAAO activity was inhibited by RNAi (Burnet et al., 2011)....
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"Pharmacodynamic Effects of a d-Amin..." refers background in this paper
...In fact, reports with intrathecal administration would suggest pronociceptive effects of spinal D-serine (Kolhekar et al., 1994; Guo et al., 2006)....
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