Pharmacodynamic monitoring of cyclosporine a in renal allograft recipients shows a quantitative relationship between immunosuppression and the occurrence of recurrent infections and malignancies.
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...Cytogenetic study revealed the classic Philadelphia chromosome: 46,XY,t(9;22)(q34;q11....
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...In September of 2003, she underwent a bone marrow biopsy and a positive Philadelphia chromosome was detected [46,XX,t(9;22)(q34;q11....
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Cites methods or result from "Pharmacodynamic monitoring of cyclo..."
...The MRE cutoffs were based on approximate cutoffs correlated with over and under immunosuppression in prior studies.(14,15) In the INT arm, MRE levels are also remeasured 6 months post enrollment and a second adjustment was made if the above criteria were met....
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...This is in line with other studies using this assay that found a well-defined low MRE cutoff associated with infection and malignancy, with a less well defined and more variable range of MRE cutoff associated with rejection.(14,15,18) And in fact, increasing tac based on a high MRE may have been responsible for more infectious complications in the INT arm....
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References
1,723 citations
"Pharmacodynamic monitoring of cyclo..." refers background in this paper
...With the introduction of calcineurin inhibitors, long-term allograft survival has significantly improved (1), primarily by reduction of acute rejection episodes....
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1,639 citations
"Pharmacodynamic monitoring of cyclo..." refers background in this paper
...Calcineurin is a key component of T-cell activation and serves as the target of the CsA cyclophilin complex (16)....
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"Pharmacodynamic monitoring of cyclo..." refers background in this paper
...However, rational means to balance both the benefits and side effects of CsA treatment are not sufficiently established yet (2, 3)....
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314 citations
"Pharmacodynamic monitoring of cyclo..." refers background in this paper
...(11) demonstrated that the immunosuppressive action for CsA, when measured as inhibition of calcineurin activity in lymphocytes, is inversely correlated with CsA blood levels....
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...In humans, peak CsA blood levels at one to two hours after oral CsA uptake resulted in a 70 to 96% inhibition of calcineurin, which was rapidly reversed when CsA blood levels came down to the trough levels (10, 11)....
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