Journal ArticleDOI
Pharmacological and nutritional agents promoting browning of white adipose tissue
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TLDR
The different physiological, pharmacological and dietary determinants that have been linked to white-to-brown fat remodeling and the molecular mechanisms involved are reviewed in detail.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-05-01. It has received 256 citations till now. The article focuses on the topics: White adipose tissue & Adipose tissue.read more
Citations
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Journal ArticleDOI
Brown and beige fat: development, function and therapeutic potential
Matthew J. Harms,Patrick Seale +1 more
TL;DR: Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.
Journal ArticleDOI
Adipose tissue browning and metabolic health
Alexander Bartelt,Joerg Heeren +1 more
TL;DR: Stimulating the development of beige adipocytes in WAT (so called 'browning') might reduce adverse effects of WAT and could help to improve metabolic health, as well as inspire new avenues to increase the capacity for adaptive thermogenesis.
Journal ArticleDOI
The browning of white adipose tissue: some burning issues.
Jan Nedergaard,Barbara Cannon +1 more
TL;DR: It is pointed to the possibility that cause and effect may on occasion be the reverse: browning agents may disrupt, for example, the fur, leading to increased heat loss, increased thermogenic demand to counteract thisHeat loss, and thus, through sympathetic nervous system activation, to enhanced UCP1 expression in white (and brown) adipose tissues.
Journal ArticleDOI
Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
Guolin Li,Guolin Li,Cen Xie,Siyu Lu,Robert G. Nichols,Yuan Tian,Licen Li,Daxeshkumar P. Patel,Yinyan Ma,Chad Brocker,Tingting Yan,Kristopher W. Krausz,Rong Xiang,Oksana Gavrilova,Andrew D. Patterson,Frank J. Gonzalez +15 more
TL;DR: It is shown that an every-other-day fasting (EODF) regimen selectively stimulates beige fat development within white adipose tissue and dramatically ameliorates obesity, insulin resistance, and hepatic steatosis.
Journal ArticleDOI
Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
Songbo Wang,Xingwei Liang,Qiyuan Yang,Xing Fu,Carl J. Rogers,Mei-Jun Zhu,Buel D. Rodgers,Qingyan Jiang,Michael V. Dodson,Min Du +9 more
TL;DR: Resveratrol induces brown-like adipocyte formation in iWAT via AMPKα1 activation and its beneficial antiobesity effects may be partly due to the browning of WAT and, as a consequence, increased oxygen consumption.
References
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Journal ArticleDOI
Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Journal ArticleDOI
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Marie Lagouge,Carmen Argmann,Zachary Gerhart-Hines,Hamid Meziane,Carles Lerin,Frédéric N. Daussin,Nadia Messadeq,Jill C. Milne,Philip D. Lambert,Peter J. Elliott,Bernard Geny,Markku Laakso,Pere Puigserver,Johan Auwerx +13 more
TL;DR: RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in P GC-1alpha acetylation and an increase in PGC-1 alpha activity.
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Brown and beige fat: development, function and therapeutic potential
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