Journal ArticleDOI
Pharmacological management of mild or moderate persistent asthma
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TLDR
A combination of this drug and long-acting inhaled beta2 agonists provides improved control compared with doubling of the maintenance dose of inhaled corticosteroids and the combination of budesonide and formoterol has been assessed as both maintenance and reliever treatment.About:
This article is published in The Lancet.The article was published on 2006-08-26. It has received 59 citations till now. The article focuses on the topics: Budesonide & Asthma.read more
Citations
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Journal ArticleDOI
The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines
TL;DR: Accumulating evidence is reviewed suggesting that histamine indeed has roles in inflammation and immune function modulation in such diseases and a possible synergy between H1 and H4-receptor antagonists in targeting various inflammatory conditions is reviewed.
Journal ArticleDOI
Internet-based self-management plus education compared with usual care in asthma: a randomized trial
Victor van der Meer,Moira J. Bakker,Wilbert B. van den Hout,Klaus F. Rabe,Peter J. Sterk,Job Kievit,Willem J J Assendelft,Jacob K. Sont +7 more
TL;DR: In this article, the authors evaluated the effectiveness of Internet-based self-management of chronic conditions, such as asthma, in a randomized controlled trial with 200 adults with asthma who were treated with inhaled corticosteroids.
Journal ArticleDOI
Eosinophils capture viruses, a capacity that is defective in asthma.
Yanaika S. Sabogal Piñeros,Suzanne M. Bal,Annemiek Dijkhuis,Christof J. Majoor,Barbara Dierdorp,Tamara Dekker,Esmée P. Hoefsmit,Peter I. Bonta,Daisy I. Picavet,Nicole N. van der Wel,Leo Koenderman,Peter J. Sterk,Lara Ravanetti,René Lutter +13 more
TL;DR: Initial murine studies led to further explore a potential intracellular antiviral activity by eosinophils, which can also display protective properties like an extracellular antivirus activity.
Journal ArticleDOI
Clinical predictors and outcomes of consistent bronchodilator response in the childhood asthma management program
Sunita Sharma,Augusto A. Litonjua,Kelan G. Tantisira,Anne L. Fuhlbrigge,Stanley J. Szefler,Robert C. Strunk,Robert S. Zeiger,Amy Murphy,Scott T. Weiss +8 more
TL;DR: B baseline clinical variables are assessed and predictors of consistent BDR are identified and it is determined that this phenotype is associated with poor clinical outcomes.
References
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Journal ArticleDOI
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
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Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study.
Eric D. Bateman,Homer A. Boushey,Jean Bousquet,William W. Busse,T. Clark,Romain Pauwels,Søren Pedersen +6 more
TL;DR: A 1-year, randomized, stratified, double-blind, parallel-group study of 3,421 patients with uncontrolled asthma, confirming that the goal of guideline-derived asthma control was achieved in a majority of the patients.
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Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group
Romain Pauwels,Claes-Göran Löfdahl,Dirkje S. Postma,Anne E. Tattersfield,Paul M. O'Byrne,Peter J. Barnes,A Ullman +6 more
TL;DR: In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
Journal ArticleDOI
Long-term effects of budesonide or nedocromil in children with asthma.
Stanley J. Szefler,Scott T. Weiss,James Tonascia,N. Franklin Adkinson,Bruce G. Bender,Reuben M. Cherniack,Michele Donithan,H William Kelly,J. Reisman,Gail G. Shapiro,Alice L. Sternberg,R.C. Strunk,Virginia S. Taggart,Mark L. Van Natta,Robert A. Wise,Margaret Wu,Robert S. Zeiger +16 more
TL;DR: In children with mild-to-moderate asthma, neither budesonide nor nedocromil is better than placebo in terms of lung function, but inhaled budesonides improves airway responsiveness and provides better control of asthma than placebo or nedOCromil.
Journal ArticleDOI
A 15-year follow-up study of ventilatory function in adults with asthma.
TL;DR: Data from a longitudinal epidemiologic study of the general population in a Danish city, the Copenhagen City Heart Study, is used to analyze changes over time in the forced expiratory volume in one second (FEV1) in adults with self-reported asthma and adults without asthma.