Pharmacological Promotion of Autophagy Alleviates Steatosis and Injury in Alcoholic and Non-alcoholic Fatty Liver Conditions in Mice
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Cites background from "Pharmacological Promotion of Autoph..."
...Resultant data indicate the possibility that ALD can be treated through modulating autophagy.(113,114) Autophagic flux can be suppressed by bile acids during cholestasis....
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...Furthermore, pharmacological up-regulation of autophagy reduces hepatotoxicity and steatosis in alcohol-treated mouse livers.(113,114) The liver responds to stressful conditions through global activation of autophagy, selectively to eliminate damaged mitochondria and accumulated lipid droplets....
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...Pharmacological modulation of autophagy in the liver can be an effective strategy for improving alcoholic and nonalcoholic fatty liver diseases.(113) Fatty acidinduced lipotoxicity is also regulated by autophagy and apoptosis....
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References
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"Pharmacological Promotion of Autoph..." refers background in this paper
...Macroautophagy (referred to here as autophagy) is an essential cellular degradation process with important pathophysiological significance [13]....
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...Although not examined in this study, other effects of autophagy, such as removing damaged mitochondria, would be also expected to play a role in enhancing the protection against liver injury [13, 18]....
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"Pharmacological Promotion of Autoph..." refers background or methods in this paper
...is a key functional index of autophagy induction [27]....
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...Autophagy was assessed as previously described [18, 27] by long lived protein degradation assay and GFP-LC3 quantification, in which cells were pre-infected with adenoviral GFP-LC3 the night before the indicated treatment....
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"Pharmacological Promotion of Autoph..." refers background in this paper
...NAFLD and AFLD seem to share a similar pathogenesis that involves progression from simple steatosis to steatohepatitis, fibrosis and cirrhosis [4,5,9]....
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...We found that both CBZ and rapamycin stimulated the reduction of hepatic steatosis and blood TG levels, which could in turn lead to an overall reduction of total cellular free fatty acids content and thus contribute to the overall reduction of liver injury [4,5,9]....
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