Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
Citations
24 citations
Cites background from "Pharmacotherapy for neuropathic pai..."
...Initial studies of amitriptyline and ketamine combinations focused on 2%/1% concentrations based on prior case studies in NP....
[...]
...[20,21] In preclinical studies, localized peripheral administration of amitriptyline produces antinociception including in models of NP.[22–27] In these studies, amitriptyline was delivered by local injection into the rodent hindpaw, and peripheral actions were validated by demonstrating actions occur in the hindpaw ipsilateral to the injection site but not on the contralateral side....
[...]
...Topical analgesics consisting of creams/gels or patches are applied directly to the surface of the skin and alter pain responses following dermal absorption and actions on peripheral aspects of sensory nerves and adjacent cellular structures, and several have been demonstrated to produce analgesia in NP.[10] This approach has the potential advantage of producing low systemic drug levels with minimal systemic AEs and drug interactions, and this safety feature allows for combining several topical agents within the same formulation, as well as with systemic agents....
[...]
...%) did not produce significant analgesia compared to placebo over 1–4 weeks in several forms of NP.[54–56]...
[...]
...An additional consideration is that AmiKet may represent a potential adjuvant or combination therapy for treatment of NP....
[...]
24 citations
24 citations
24 citations
24 citations
Cites background from "Pharmacotherapy for neuropathic pai..."
...Management of pain should follow the guidelines drawn for neuropathic pain in general, with gabapentinoids, SNRIs, and tricyclics used initially, and opioids reserved for severe cases only (106)....
[...]
References
62,157 citations
46,935 citations
37,989 citations
15,740 citations
13,324 citations