Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
Citations
34 citations
34 citations
34 citations
Cites background from "Pharmacotherapy for neuropathic pai..."
...The shortage of pharmacological agents able to treat neuropathic pain, a quite prevalent form of chronic pain, represents an increasingly medical burden (Finnerup et al., 2015)....
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34 citations
Cites methods from "Pharmacotherapy for neuropathic pai..."
...A recent systematic review according to Grading of Recommendations Assessment, Development, and Evaluation criteria (GRADE) [118] including the analysis of publication bias [119] and unpublished trials showed weak quality of evidence on the effectiveness of BTX-A in neuropathic pain and recommended this agent as a third-line treatment [120]....
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34 citations
Cites background or methods from "Pharmacotherapy for neuropathic pai..."
...Limited clinical experience Cutaneous patches I + A/C Casale et al,19 Meier et al20 and Irving et al21 Mixed evidence and results for localized NeP....
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...Good evidence on efficacy was found for the combination of pregabalin/gabapentin and opioids in RCTs by Gilron et al16 (2400 mg gabapentin plus 60 mg morphine), Hanna et al17 (flexible moderate-dose gabapentin plus flexible moderate-dose oxycodone) and by Caraceni et al18 (fix-dose oxycodone plus moderate flexible-dose gabapentin [maximum 1800 mg]) in peripheral NeP....
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...The scientific evidence is, however, divergent, dependent on the type of NeP....
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...However, neither sodium channel blockers such as lamotrigine nor multiple modes of action drugs such as topiramate have any certain role in the treatment of NeP.(7) In general, this combination was seldom used by the experts....
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...The combination of pregabalin/gabapentin and TCAs was the best documented and experts had good clinical experience with this combination in the management of NeP....
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References
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