Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
Citations
32 citations
Cites background or result from "Pharmacotherapy for neuropathic pai..."
...Most of the treatments usually available have a modest efficacy or safety.(6,16) Therefore, new therapeutic prospects are welcome....
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...Unfortunately, meta-analyses indicate that only a minority of patients with neuropathic pain have adequate response to drug therapy and that many of these drugs have dose-limiting side effects.(6,16) Other drugs expected to be effective such as oromucosal cannabinoids, the opioid agonist, and norepinephrine reuptake inhibitor tapentadol and several antiepileptics (lamotrigine, oxcarbazepine, and topiramate) have yielded discrepant results, although some of them may be effective in subgroups of patients (see below)....
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...and despite evidence for clinical efficacy in neuropathic pain, strong opioids are now recommended as the last choice in case of insufficient response and/or side effects to first-line or secondline medications with careful monitoring.(16)...
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...These data have led to recommend BTX-A as a third choice in the therapeutic arsenal of peripheral neuropathic pain for refractory patients.(16) Table 1...
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32 citations
Cites background from "Pharmacotherapy for neuropathic pai..."
...Hence, genomics could be helpful in stratifying subgroups of patients in whom treatments are potentially more effective, improving the therapeutic index of drugs in pain therapy.(70) Nowadays precision medicine is a great opportunity with a revolutionary impact on the “health system”, especially in terms of effectiveness, safety, ethics and cost savings....
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32 citations
32 citations
Cites background from "Pharmacotherapy for neuropathic pai..."
...The recommended pharmacotherapy for neuropathic pain includes the use of anticonvulsant drugs, such as the gabapentinoids, pregabalin, and gabapentin.(3) (1)Institut des Neurosciences Cellulaires et Intégratives, Centre National de la...
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...Gabapentinoid anticonvulsants, which target the VDCCs a2d-1 subunit, have proved to be effective in a number of neuropathic pain conditions.(3,39) Similarly to many reports in various animal models,(6,20,40,41) we showed that pregabalin has a shortterm transitory antiallodynic action after an acute administration; however, this effect cannot be considered as representative of the main clinical therapeutic effect since the mechanical allodynia reappears within 2 h following the injection....
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31 citations
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