Phenotypic Polarization of Macrophages in Atherosclerosis
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TLDR
A novel view of the function of macrophages in the development of atherosclerosis that suggests dynamic plasticity is suggested and revealing the functional characteristics of individual macrophage phenotypes will lead to a better understanding of their contribution to lesion development and plaque stability.Abstract:
Macrophages orchestrate the inflammatory response in inflamed tissues, and recent work indicates that these cells can alter their phenotypes and functions accordingly in response to changes in the microenvironment. Initial work in models of cardiovascular disease used immunologic markers to characterize macrophage phenotypes present in atherosclerotic plaque, and these studies have lately been extended through the use of markers that are more specific for atherosclerosis and metabolic disease. Together, these studies have led to a novel view of the function of macrophages in the development of atherosclerosis that suggests dynamic plasticity. Understanding this plasticity and the ensuing macrophage heterogeneity could lead to novel strategies of pharmacological intervention to combat chronic inflammation in metabolic diseases. Most importantly, revealing the functional characteristics of individual macrophage phenotypes will lead to a better understanding of their contribution to lesion development and plaque stability.read more
Citations
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TL;DR: The current understanding of the roles of different cytokines in atherosclerosis together with therapeutic approaches aimed at manipulating their actions are described.
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TL;DR: The current understanding of the contributions of differentially polarized macrophages to various infectious and inflammatory diseases and the ongoing effort to develop novel therapies that target this key aspect of macrophage biology are summarized.
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MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease
Maarten Hulsmans,Paul Holvoet +1 more
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References
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Kathryn J. Moore,Ira Tabas +1 more
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Journal ArticleDOI
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