Phosphatidylserine-containing liposomes suppress inflammatory bone loss by ameliorating the cytokine imbalance provoked by infiltrated macrophages.
Citations
744 citations
Cites background from "Phosphatidylserine-containing lipos..."
...Furthermore, recent studies have shown that liposome administration can alter macrophage phenotype in vivo in part by induction of ERK signaling after ingestion (53, 54)....
[...]
152 citations
Cites background from "Phosphatidylserine-containing lipos..."
...[77] suggests that this effect is due to increased IL-10 production by macrophages....
[...]
70 citations
64 citations
Cites background from "Phosphatidylserine-containing lipos..."
...In vivo, PSLs have been described to promote the resolution of inflammation by modulating macrophage function in a model for inflammatory bone loss and myocardial infarction [31,33]....
[...]
...In vitro, clearance of apoptotic cells and PSLs skews macrophages towards a tolerogenic phenotype [21,23,29-35]....
[...]
55 citations
References
3,348 citations
2,978 citations
2,273 citations
2,242 citations
1,843 citations
"Phosphatidylserine-containing lipos..." refers background in this paper
...(RANKL) and RANK, which have essential roles in differentiation and the activity of osteoclasts.(18) Among pro-inflammatory cytokines, interleukin (IL)-1b is...
[...]