Phosphatidylserine-containing liposomes suppress inflammatory bone loss by ameliorating the cytokine imbalance provoked by infiltrated macrophages.
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TLDR
PSL-induced different influence on the activities of p38 MAPK and ERK is a likely underlying mechanism for phenotypic change of infiltrated macrophages after the phagocytosis of PSLs, resulting in the inhibition of inflammatory bone loss.About:
This article is published in Laboratory Investigation.The article was published on 2011-06-01 and is currently open access. It has received 52 citations till now. The article focuses on the topics: Interleukin 10 & Phagocytosis.read more
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Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Prakash Ramachandran,Antonella Pellicoro,Madeleine A. Vernon,Luke Boulter,Rebecca L. Aucott,Aysha Ali,Stephen N. Hartland,Victoria K. Snowdon,Andrea Cappon,Timothy T. Gordon-Walker,Mike J. Williams,Donald R. Dunbar,Jonathan R. Manning,Nico van Rooijen,Jonathan A. Fallowfield,Stuart J. Forbes,John P. Iredale +16 more
TL;DR: The restorative macrophage phenotype was recapitulated in vitro by the phagocytosis of cellular debris with associated activation of the ERK signaling cascade, offering a therapeutic strategy to this orphan pathological process.
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Pathways for Bone Loss in Inflammatory Disease
Tobias Braun,Georg Schett +1 more
TL;DR: This review summarizes new data on inflammatory bone loss obtained in 2011 and describes the molecular pathways by which receptor activator of nuclear factor-κB ligand and RANKL induce osteoclast differentiation.
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HCMV reprogramming of infected monocyte survival and differentiation: a Goldilocks phenomenon.
Emily V. Stevenson,Donna Collins-McMillen,Jung Heon Kim,Stephen J. Cieply,Gretchen L. Bentz,Andrew D. Yurochko +5 more
TL;DR: The induction of a uniquely polarized macrophage subset from infected monocytes is described, which is argued to be the ideal cellular environment for the initiation of viral gene expression and replication and, ultimately, viral spread and persistence within the infected host.
Journal ArticleDOI
Myelin alters the inflammatory phenotype of macrophages by activating PPARs
Jeroen F. J. Bogie,Winde Jorissen,Jo Mailleux,Philip G. Nijland,Noam Zelcer,Tim Vanmierlo,Jack van Horssen,Piet Stinissen,Niels Hellings,Jerome J. A. Hendriks +9 more
TL;DR: The data show that myelin modulates the phenotype of macrophages by PPAR activation, which may subsequently dampen MS lesion progression and the immunoregulatory impact of naturally-occurring myelin lipids may hold promise for future MS therapeutics.
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Anti-obesity and anti-inflammatory effects of macrophage-targeted interleukin-10-conjugated liposomes in obese mice.
TL;DR: The findings suggest that the PSL-IL10 has macrophage targeting ability and enhanced anti- inflammatory effect due to the synergistic anti-inflammatory effects of IL-10 and PSL, and can be used as amacrophage-targeted therapeutic material for inflammation-related diseases, including obesity.
References
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Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
TL;DR: In vivo that direct instillation of apoptotic cells enhanced the resolution of acute inflammation, and apoptotic cell recognition and clearance, via exposure of PS and ligation of its receptor, induce TGF-beta1 secretion, resulting in accelerated resolution of inflammation.
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RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
Ji Li,Ildiko Sarosi,Xiao-Qiang Yan,Sean Morony,Casey Capparelli,Hong-Lin Tan,Susan McCabe,Robin Elliott,Sheila Scully,Gwyneth Van,Stephen J. Kaufman,Shao-Chieh Juan,Yu Sun,John E. Tarpley,Laura Martín,Kathleen Christensen,James McCabe,Paul J. Kostenuik,Hailing Hsu,Frederick A. Fletcher,Colin R. Dunstan,David L. Lacey,William J. Boyle +22 more
TL;DR: Data indicate that RANK is the intrinsic cell surface determinant that mediates osteoprotegerin ligand effects on bone resorption and remodeling as well as the physiological and pathological effects of calciotropic hormones and proresorptive cytokines.
Journal ArticleDOI
Modulation of Osteoclast Differentiation
TL;DR: Osteotropic hormones such as 1α, 25-dihydroxyvitamin D3 [1α,25(OH)2D3], PTH, and calcitonin preferentially modulate the process of bone resorption to maintain bone remodeling.
Journal ArticleDOI
Resolution of inflammation: state of the art, definitions and terms.
Charles N. Serhan,Susan D. Brain,Christopher D. Buckley,Derek W. Gilroy,Christopher Haslett,Luke A. J. O'Neill,Mauro Perretti,Adriano G. Rossi,John L. Wallace +8 more
TL;DR: A consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti‐inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today.
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Endotoxin signal transduction in macrophages
Matthew J. Sweet,David A. Hume +1 more
TL;DR: The effects of LPS on macrophages are examined by following events from the cell surface to the nucleus and the involvement of protein tyrosine kinase, mitogen‐activated protein kinases, protein kinase C, G proteins, Protein kinase A, ceramide‐activatedprotein kinase and microtubules in this process are reviewed.