Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network
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"Phospholipase D Stimulates Release ..." refers background in this paper
...The essential role ARF1 plays in vesicle trafficking (Donaldson and Klausner, 1994; Rothman, 1994), its regulation of PLD (Brown et al., 1993; Kahn et al., 1993; Cockcroft et al., 1994; Liscovitch and Cantley, 1995), the presence of an ARF-regulated form of PLD in Golgi membranes (Ktistakis et al.,…...
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...The essential role ARF1 plays in vesicle trafficking (Donaldson and Klausner, 1994; Rothman, 1994), its regulation of PLD (Brown et al....
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925 citations
"Phospholipase D Stimulates Release ..." refers background in this paper
...Earlier work (Herman et al., 1992; Schu et al., 1993; Stack and Emr, 1994) demonstrated that the yeast VPS34 gene encodes a PtdIns-3-kinase that is essential for protein transport from the Golgi apparatus to the vacuole....
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924 citations
"Phospholipase D Stimulates Release ..." refers background in this paper
...M ammalian phosphatidylcholine–specific phospholipase D (PLD) 1 has been implicated in a wide range of physiological responses including metabolic regulation, cell proliferation, mitogenesis, oncogenesis, inflammation, secretion, and diabetes (Exton, 1994)....
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...M ammalian phosphatidylcholine–specific phospholipase D (PLD) 1 has been implicated in a wide range of physiological responses including metabolic regulation, cell proliferation, mitogenesis, oncogenesis, inflammation, secretion, and diabetes (Exton, 1994)....
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875 citations
"Phospholipase D Stimulates Release ..." refers background or methods in this paper
...line as substrate in the presence of GTP g S and ARF (Brown et al., 1993),...
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...Evidence from several laboratories has shown that ARF and PLD co-chromatograph through several purification steps suggesting a direct interaction (Brown et al., 1993; Siddiqi et al., 1995) and ARF and purified PLD do interact in phospholipid micelles (Hammond et al....
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...The essential role ARF1 plays in vesicle trafficking (Donaldson and Klausner, 1994; Rothman, 1994), its regulation of PLD (Brown et al., 1993; Kahn et al., 1993; Cockcroft et al., 1994; Liscovitch and Cantley, 1995), the presence of an ARF-regulated form of PLD in Golgi membranes (Ktistakis et al....
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...The eluate was neutralized immediately, dialyzed against incubation buffer, and assayed for PLD activity (Brown et al., 1993)....
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...The above results, together with the observation that ARF can activate PLD (Brown et al., 1993; Cockcroft et al., 1994; Ktistakis et al., 1995, 1996), suggested that ARF stimulation of nascent vesicle budding might occur via PLD activation....
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724 citations
"Phospholipase D Stimulates Release ..." refers background in this paper
...Evidence from several laboratories has implicated phospholipid-modifying enzymes and inositol phospholipid metabolism in mediating various steps of intracellular vesicular transport (Boman and Kahn, 1995; Liscovitch and Cantley, 1995; De Camilli et al., 1996)....
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...…coatomer to Golgi membranes (Ktistakis et al., 1995, 1996) and the increasing evidence that phospholipid-modifying enzymes play a role in membrane trafficking (Liscovitch and Cantley, 1995; De Camilli et al., 1996), we hypothesized that PLD could be a link between ARF and secretory vesicle release....
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