Physical, chemical and pharmacological characterization of a new oleogel-forming triterpene extract from the outer bark of birch (betulae cortex).
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...The chromatographic separation was performed using GC-FID and HPLC-UV respectively and the chromatograms were inspected visually for peak purity of spiked triterpenes....
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...The measured amounts, listed in Table 2, show the dominance of BE in birch bark [15]....
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...We previously reported an extraction method with heated n-heptane, were a triterpene dry extract (TE) of birch bark is formed [13,15]....
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...This extraction and quantification method was validated and described for birch bark and mistletoe sprouts [15,22]....
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...The accelerated solvent extraction (ASE) method presented here reaches complete extraction within 45 min without any further clean-up step prior to GC-FID of silylated triterpenes [15,22]....
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...This triterpene extract displays antiproliferative and pro-apoptotic effects in human squamous cell carcinoma cells in vitro.([111]) In a prospective non-randomized study it has been shown that an ointment prepared from betulin is an effective treatment (79% responders) of actinic keratoses that represent in situ squamous cell carcinomas([112]) [LOE-B]....
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