Journal ArticleDOI
Physiological changes in neurodegeneration — mechanistic insights and clinical utility
Rebekah M. Ahmed,Rebekah M. Ahmed,Yazi D. Ke,Steve Vucic,Lars M. Ittner,Lars M. Ittner,William W. Seeley,John R. Hodges,John R. Hodges,Olivier Piguet,Olivier Piguet,Glenda M. Halliday,Matthew C. Kiernan,Matthew C. Kiernan +13 more
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TLDR
The changes and similarities between disorders might provide novel insights into the human neural correlates of physiological functioning and could provide biomarkers to aid in the early diagnosis of neurodegenerative diseases and in treatment trials.Abstract:
The effects of neurodegenerative syndromes extend beyond cognitive function to involve key physiological processes, including eating and metabolism, autonomic nervous system function, sleep, and motor function. Changes in these physiological processes are present in several conditions, including frontotemporal dementia, amyotrophic lateral sclerosis, Alzheimer disease and the parkinsonian plus conditions. Key neural structures that mediate physiological changes across these conditions include neuroendocrine and hypothalamic pathways, reward pathways, motor systems and the autonomic nervous system. In this Review, we highlight the key changes in physiological processing in neurodegenerative syndromes and the similarities in these changes between different progressive neurodegenerative brain conditions. The changes and similarities between disorders might provide novel insights into the human neural correlates of physiological functioning. Given the evidence that physiological changes can arise early in the neurodegenerative process, these changes could provide biomarkers to aid in the early diagnosis of neurodegenerative diseases and in treatment trials.read more
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Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition
Wei-Na Jin,Wei-Na Jin,Kaibin Shi,Wenyan He,Jun-Hong Sun,Luc Van Kaer,Fu-Dong Shi,Fu-Dong Shi,Qiang Liu +8 more
TL;DR: It is demonstrated that NK cell accumulation in the aging brain impairs neurogenesis, which may serve as a therapeutic target to improve cognition in the aged population.
Journal ArticleDOI
Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders.
Eryn L. Werry,Fiona Bright,Olivier Piguet,Lars M. Ittner,Glenda M. Halliday,John R. Hodges,Matthew C. Kiernan,Matthew C. Kiernan,Clement T. Loy,Jillian J. Kril,Michael Kassiou +10 more
TL;DR: This review details recent developments in exploration of ligand-sensitivity to A147T TSPO that have yielded ligands with improved clinical utility and develops an understanding of the cellular and functional interpretation of the TSPo PET signal.
Clinicopathological correlations in behavioural variant frontotemporal dementia
David C. Perry,Jesse A. Brown,Katherine L. Possin,Samir Datta,Andrew Trujillo,Anneliese Radke,Anna Karydas,John Kornak,Ana C. Sias,Gil D. Rabinovici,Maria Luisa Gorno-Tempini,Adam L. Boxer,Mary De May,Katherine P. Rankin,Virginia E. Sturm,Suzee E. Lee,Brandy R. Matthews,Aimee W. Kao,Keith A. Vossel,Maria Carmela Tartaglia,Zachary A. Miller,Sang Won Seo,Manu Sidhu,Stephanie E. Gaus,Alissa L. Nana,Jose Norberto S. Vargas,Ji-Hye L. Hwang,Rik Ossenkoppele,Alainna B. Brown,Eric J. Huang,Giovanni Coppola,Howard J. Rosen,Daniel H. Geschwind,John Q. Trojanowski,Lea T. Grinberg,Joel H. Kramer,Bruce L. Miller,William W. Seely +37 more
TL;DR: Voxel-based morphometry revealed that nearly all pathological subgroups and even individual patients share atrophy in anterior cingulate, frontoinsula, striatum, and amygdala, indicating that degeneration of these regions is intimately linked to the behavioural syndrome produced by these diverse aetiologies.
Journal ArticleDOI
Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease
Sina K. Stumpf,Stefan A. Berghoff,Andrea Trevisiol,Lena Spieth,Tim Düking,Lennart V. Schneider,Lennart Schlaphoff,Steffi Dreha-Kulaczewski,Annette Bley,Dinah Burfeind,Kathrin Kusch,Miso Mitkovski,Torben Ruhwedel,Philipp Guder,Heiko Röhse,Jonas Denecke,Jutta Gärtner,Wiebke Möbius,Wiebke Möbius,Klaus-Armin Nave,Klaus-Armin Nave,Gesine Saher +21 more
TL;DR: It is suggested that a therapy with lipids such as ketone bodies, that readily enter the brain, can circumvent the requirement of a disrupted blood–brain barrier in the treatment of myelin disease.
Journal ArticleDOI
The functional neuroanatomy of emotion processing in frontotemporal dementias.
Charles R. Marshall,Charles R. Marshall,Chris J.D. Hardy,Lucy L. Russell,Rebecca L. Bond,Harri Sivasathiaseelan,Caroline V. Greaves,Katrina M. Moore,Jennifer L. Agustus,Janneke E P van Leeuwen,Stephen J Wastling,Jonathan D. Rohrer,James M. Kilner,Jason D. Warren +13 more
TL;DR: The functional neuroanatomy of aberrant emotion processing across the spectrum of frontotemporal dementia is reported, demonstrating abnormalities at multiple hierarchical levels including sensory processing, emotion categorisation and autonomic reactivity.
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