Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling
Citations
38 citations
Cites background from "Physiological Dynamics in Demyelina..."
...It has been suggested that in the healthy condition axons and their microscopic substructures (e.g., their g-ratio) are finely tuned biological devices and that changes of their composition can lead to clinical syndromes [Coggan et al., 2015]....
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..., their g-ratio) are finely tuned biological devices and that changes of their composition can lead to clinical syndromes [Coggan et al., 2015]....
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38 citations
25 citations
Cites background from "Physiological Dynamics in Demyelina..."
...As the central nervous system appears to communicate at physical limits to constrain metabolic demands (Salami et al., 2003; Hartline and Colman, 2007; Coggan et al., 2015), small deviations from the optimal g-ratio value (0....
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15 citations
References
8,883 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...The differential diagnosis of MS closely follows the McDonald criteria [17]....
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3,162 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...[46] proposed four distinct immunopatterns of plaque formation found in patients at different stages of the disease....
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...Other factors causing axonal dysfunction or death include a lack of trophic support from myelin and oligodendrocytes, damage from soluble or cellular immune factors still present in the inactive plaque, and chronic mitochondrial failure in the setting of increased energy demands [46]....
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2,315 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...the first thorough explanation of AP generation, was derived from experiments in unmyelinated giant axons of squid [63,64], but this early model has proven to be an invaluable tool from which later, more sophisticated models of myelinated axons have evolved....
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2,079 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...Transition from RRMS to SPMS is foreboding for the lack of therapeutics to combat the exacerbated physical and cognitive deterioration that most SPMS patients face [9,37]....
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1,813 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...Regulatory lymphocytes (Tregs) fail to suppress effector cells-mostly cytotoxic CD8+ cells [51]....
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