Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling
Citations
38 citations
Cites background from "Physiological Dynamics in Demyelina..."
...It has been suggested that in the healthy condition axons and their microscopic substructures (e.g., their g-ratio) are finely tuned biological devices and that changes of their composition can lead to clinical syndromes [Coggan et al., 2015]....
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..., their g-ratio) are finely tuned biological devices and that changes of their composition can lead to clinical syndromes [Coggan et al., 2015]....
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38 citations
25 citations
Cites background from "Physiological Dynamics in Demyelina..."
...As the central nervous system appears to communicate at physical limits to constrain metabolic demands (Salami et al., 2003; Hartline and Colman, 2007; Coggan et al., 2015), small deviations from the optimal g-ratio value (0....
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15 citations
References
51 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...Other studies using bifurcation analysis suggest that ion concentration changes can introduce slow dynamics that may be important for understanding pathological outcomes [94,109]....
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50 citations
44 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...system [113], those related to MS typically model genetic interaction networks, either represented as sets of ordinary differential equations (ODEs) or Boolean networks....
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42 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...a possible cellular mechanism of RRMS found breakdown in homeostasis of effector (Teff) and regulatory T (Treg) cells [114,115]....
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41 citations
Additional excerpts
...A computational approach will be necessary for integrating parallel and multifactorial etiologies associated with cognitive decline such as immune system signaling, energy metabolism, grey and white matter interactions, and genetic networks [117]....
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