Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling
Citations
38 citations
Cites background from "Physiological Dynamics in Demyelina..."
...It has been suggested that in the healthy condition axons and their microscopic substructures (e.g., their g-ratio) are finely tuned biological devices and that changes of their composition can lead to clinical syndromes [Coggan et al., 2015]....
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..., their g-ratio) are finely tuned biological devices and that changes of their composition can lead to clinical syndromes [Coggan et al., 2015]....
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38 citations
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Cites background from "Physiological Dynamics in Demyelina..."
...As the central nervous system appears to communicate at physical limits to constrain metabolic demands (Salami et al., 2003; Hartline and Colman, 2007; Coggan et al., 2015), small deviations from the optimal g-ratio value (0....
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References
15 citations
"Physiological Dynamics in Demyelina..." refers methods in this paper
...Broome and Coleman [111] demonstrated the power of this technique by modeling several biochemical pathways in neurons associated with cell death during MS including reactive oxygen and nitrogen species formation, Ca2+ dynamics, death complex formation, apoptotic factor release, and inflammatory responses together with three different states: normal, MS disease and treatment....
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...Broome and Coleman [111] demonstrated the power of this technique by modeling several biochemical pathways in neurons...
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"Physiological Dynamics in Demyelina..." refers background in this paper
...different regions of the same neuron [59]....
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...could, in theory at least, involve interactions between different regions of the neuron [59]....
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