Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling
Citations
38 citations
Cites background from "Physiological Dynamics in Demyelina..."
...It has been suggested that in the healthy condition axons and their microscopic substructures (e.g., their g-ratio) are finely tuned biological devices and that changes of their composition can lead to clinical syndromes [Coggan et al., 2015]....
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..., their g-ratio) are finely tuned biological devices and that changes of their composition can lead to clinical syndromes [Coggan et al., 2015]....
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38 citations
25 citations
Cites background from "Physiological Dynamics in Demyelina..."
...As the central nervous system appears to communicate at physical limits to constrain metabolic demands (Salami et al., 2003; Hartline and Colman, 2007; Coggan et al., 2015), small deviations from the optimal g-ratio value (0....
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15 citations
References
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"Physiological Dynamics in Demyelina..." refers methods in this paper
...Goldman & Albus [66] modified this model to include a description of the nodal membrane derived from experimental data on Xenopus laevis myelinated nerve fibers as determined by Frankenhaeuser & Huxley [67]....
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...Goldman & Albus [66] modified this model to include a description of...
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253 citations
"Physiological Dynamics in Demyelina..." refers background in this paper
...In chronic active plaques, axonal loss of 20%–80% is apparent within peri-plaque white matter and normal distant white matter [45]....
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