Journal ArticleDOI
Physiological role of hydrogen sulfide and polysulfide in the central nervous system.
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TLDR
It is demonstrated that H2S is a neuromodulator that facilitates hippocampal long-term potentiation (LTP) by enhancing the activity of N-methyl-D-aspartate (NMDA) receptors and also functions as a neuroprotective agent by enhances the production of glutathione, a major intracellular antioxidant that scavenges the reactive oxygen species in the mitochondria.About:
This article is published in Neurochemistry International.The article was published on 2013-11-01. It has received 228 citations till now. The article focuses on the topics: Cystathionine beta synthase & Cysteine.read more
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International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors.
TL;DR: The present article overviews the currently known H 2S donors and H2S biosynthesis inhibitors, delineates their mode of action, and offers examples for their biologic effects and potential therapeutic utility.
Journal ArticleDOI
Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides
TL;DR: A H2 Sn-mediated benzodithiolone formation under mild conditions is reported and specific fluorescent probes for H2Sn are prepared and evaluated, showing good selectivity and sensitivity.
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Near-infrared fluorescent probe for imaging mitochondrial hydrogen polysulfides in living cells and in vivo.
TL;DR: The probe Mito-ss replies a turn-on fluorescence signal and exhibits a higher selectivity toward H2Sn than other abundant competing biothiols, such as glutathione, cysteine and H2S, providing a potentially powerful approach for probing H2 Sn in biological systems.
Journal ArticleDOI
Hydrogen sulfide: a neuromodulator and neuroprotectant in the central nervous system.
Xingzhou Zhang,Jin-Song Bian +1 more
TL;DR: This Review summarizes the current understanding of H2S in the central nervous system, with emphasis on its role as a neuromodulator and a neuroprotectant.
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In Vivo Analysis with Electrochemical Sensors and Biosensors.
TL;DR: This work presents a probabilistic analysis of the response of the E-modulus of the H2O2/O2 mixture to E-O2 levels through a variety of experimental procedures, including “catastrophic” chemoreception, “superficial” and “analsis”.
References
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Journal ArticleDOI
Tripartite synapses : Glia, the unacknowledged partner
TL;DR: It is suggested that perisynaptic Schwann cells and synaptically associated astrocytes should be viewed as integral modulatory elements of tripartite synapses.
Journal ArticleDOI
The possible role of hydrogen sulfide as an endogenous neuromodulator
Kazuho Abe,Hideo Kimura +1 more
TL;DR: It is shown that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation, suggesting that endogenous H 2S functions as a neuromodulator in the brain.
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The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
TL;DR: It is demonstrated that H2S is an important endogenous vasoactive factor and the first identified gaseous opener of KATP channels in vascular SMCs and production from vascular tissues was enhanced by nitric oxide.
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Glutamate-mediated astrocyte-neuron signalling.
Vladimir Parpura,Trent A. Basarsky,Fang Liu,Ksenija Jeftinija,Srdija Jeftinija,Philip G. Haydon +5 more
TL;DR: Astrocytes regulate neuronal calcium levels through the calcium-dependent release of glutamate, and an NMDA (N-methyl-d-aspartate) receptor-mediated increase in neuronal calcium is demonstrated.
Journal ArticleDOI
Carbon monoxide: a putative neural messenger.
TL;DR: In primary cultures of olfactory neurons, zinc protoporphyrin-9, a potent selective inhibitor of heme oxygenase, depletes endogenous guanosine 3',5'-monophosphate (cGMP), suggesting that carbon monoxide may be a physiologic regulator of cGMP.
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The possible role of hydrogen sulfide as an endogenous neuromodulator
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