Physiology of obesity and effects on lung function.
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Additional excerpts
...Nonwhite 62 (31) 93 (22) 177 (42) 45 (13) 113 (18)...
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...(%) 35/195 (18) 112/421 (27) 142/422 (34) 89/335 (27) 221/622 (36)...
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432 citations
Cites background from "Physiology of obesity and effects o..."
...Alternatively, increasing BMI is associated with increased frequency of small airways closure, and the resulting increased aerosol generation during airway reopening as described above may explain the stronger association of BMI with fine than coarse aerosols and lack of association with NP swabs (31)....
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References
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"Physiology of obesity and effects o..." refers background in this paper
...increased in extremely obese subjects (42, 44), probably as a...
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...The RV is usually well preserved (5, 11, 48, 63, 67), and the RV-to-TLC ratio remains normal or slightly increased (5, 28)....
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...result of the increase in blood volume (42)....
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...that lung CO-diffusing capacity is normal (15, 42, 53, 57), even...
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...A reduction in the downward movement of the diaphragm, due to increased abdominal mass, is likely to decrease TLC by limiting the room for lung expansion on inflation....
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511 citations
"Physiology of obesity and effects o..." refers background in this paper
...Obesity is characterized by a stiffening of the total respiratory system (35), which is presumed to be due to a combination of effects on lung and chest wall compliance (41)....
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...Studies of conscious, spontaneously breathing subjects have suggested that there is a reduction in chest wall compliance in obesity (35)....
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508 citations
437 citations
"Physiology of obesity and effects o..." refers background in this paper
...However, specific airway resistance, calculated by adjusting for the lung volume at which the measurements were made, is in the normal range (36, 44, 65, 67), so that the apparent reduction in airway caliber in the obese is attributable to the reduction in lung volumes rather than to airway obstruction....
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...Most studies have demonstrated a reduction in lung compliance in obese individuals (21, 40, 41, 53) that appears to be exponentially related to BMI (40)....
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...Similarly, expiratory flows decrease with increasing weight (5, 44), in proportion to the lung volumes (67)....
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...The RV is usually well preserved (5, 11, 48, 63, 67), and the RV-to-TLC ratio remains normal or slightly increased (5, 28)....
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...Lung volumes were only loosely associated with BMI, but both DXA and non-DXA-derived variables reflecting upper body fat had highly significant negative correlations with FRC and ERV in both men and women....
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