Phytochemicals As Chemosensitizers: From Molecular Mechanism to Clinical Significance
Citations
537 citations
Cites background from "Phytochemicals As Chemosensitizers:..."
...Autophagy is an evolutionarily conserved mechanism for degradation for the maintenance of intracellular homeostasis [9]....
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...Chemotherapeutic drugs induce autophagy along with apoptosis, and autophagy exerts its cyto-protective effect by degrading the drug molecules, helping cancer cells evade apoptosis [9]....
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356 citations
Cites background from "Phytochemicals As Chemosensitizers:..."
...This occurs also as an initial response to many of the degenerative changes occurring during aging, although in most of these situations the actual disease is related to subsequent loss of medial smooth muscle cells [71]....
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...Collagen fibers exposed to mechanical stress eventually degenerate [71], and therefore need to be repaired and maintained by continuous synthesis of new collagen....
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175 citations
Cites background from "Phytochemicals As Chemosensitizers:..."
...A number of phytochemicals available exhibit chemopreventive effect and sensitize cancer cells toward DOX [13]....
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139 citations
124 citations
Cites background from "Phytochemicals As Chemosensitizers:..."
...However, the clinical application of DOX has been severely hindered because of its critical cardiotoxicity, narrow therapeutic window, and the development of MDR.13 In some cancer cell studies, improved MDR and increased apoptosis have been reported with treatment of the NP-based combination therapy of DOX and chemosensitizers (ie, TNF-related apoptosis-inducing ligand, verapamil, Bcl-2 small interfering [si]RNA, and P-gp siRNA).14–17 Curcumin (Cur), the polyphenol constituent of the perennial herb Curcuma longa, exhibits antioxidant, antiinflammatory, antiangiogenic, antimicrobial, and anticancer activities.18 It also acts as a chemosensitizer to suppress the overexpression of P-glycoprotein to reverse MDR in ovarian adenocarcinoma cells.19 However, its extremely low water solubility and poor bioavailability have impeded its clinical use.20 To date, several studies have demonstrated the enhanced anticancer efficacy of the codelivery of DOX and Cur in nanocarriers, including polymeric NPs21–23 and liposomes24 in chronic myelogenous leukemia, lung, and breast cancers....
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...of cytotoxic and chemosensitizing agents exhibited better performance in the intracellular microenvironment, and are thus highlighted as more effective for tumor localization and for overcoming MDR.(6,7) Despite the benefits of combination therapy, the nanoparticle (NP)-based targeted drug delivery (nanocarriers) has been designed to increase drug accumulation at tumor sites to improve permeability and retention,(8) pharmacokinetic profiles, and reduce side effects....
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...For example, the combination of anticancer agents targeting multiple pathways, or a combination of chemotherapy with chemosensitizers has been shown to modulate different signaling pathways in cancer cells, which is beneficial to overcome multidrug resistance (MDR), maximize the therapeutic effect, and reduce side effects.4–6 Compared with a multiagent combination, the combination correspondence: Wei liu college of life science and Technology, huazhong University of science and Technology, 1037 luoyu road, Wuhan 430074, People’s republic of china Tel +86 27 877 921 47 Fax +86 27 877 922 34 email wliu@hust.edu.cn Yusang li Department of Pharmacology, college of Pharmacy, south-central University for Nationalities, 182 Minyuan road, Wuhan 430074, People’s republic of china Tel +86 27 6784 2332 Fax +86 27 6784 2332 email liys2006@mail.scuec.edu.cn In te rn at io na l J ou rn al o f N an om ed ic in e do w nl oa de d fr om h ttp s: //w w w .d ov ep re 2 F or p er so na l u se o nl y. International Journal of Nanomedicine 2015:10submit your manuscript | www.dovepress.com Dovepress Dovepress 258 Zhao et al of cytotoxic and chemosensitizing agents exhibited better performance in the intracellular microenvironment, and are thus highlighted as more effective for tumor localization and for overcoming MDR.6,7 Despite the benefits of combination therapy, the nanoparticle (NP)-based targeted drug delivery (nanocarriers) has been designed to increase drug accumulation at tumor sites to improve permeability and retention,8 pharmacokinetic profiles, and reduce side effects.9,10 Therefore, the delivery of a chemotherapeutic agent and chemosensitizer using nanocarriers has been suggested as a novel and promising strategy in cancer treatment.11,12 DOX, an anthracycline antibiotic, is one of the most efficacious drugs in the treatment of liver cancer....
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References
10,532 citations
"Phytochemicals As Chemosensitizers:..." refers background in this paper
...Moreover, elevated p21Waf1 levels conferred by HER2/neu signaling can also bring about changes in the G2/M transition, and help evade cell death induced by chemotherapeutic drugs (99)....
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...Emodin-mediated reduction in tyrosine phosphorylation of HER2/neu suppresses the proliferation of HER2/neu-overexpressing nonsmall cell lung cancer cells and sensitizes these cells to the cytotoxic activity of cisplatin in a synergistic manner (329)....
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...Tamoxifen Hormone (SERM) Uterine and endometrial cancer, liver damage, agranulocytosis, and hemolytic anemia (46) NF-jB (172), Akt (50), HER2/neu (62, 276)...
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...Emodin is a tyrosine kinase inhibitor and is shown to inhibit HER2/neu tyrosine kinase activity that leads to a preferential suppression of growth, represses the transformation of HER2/neu overexpressing breast cancer cells (328), and sensitizes these cells to paclitaxel in nude mice models (330)....
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...Signaling through human epidermal growth factor receptor 2/neuregulin (HER2/neu) is another growth factor 1312 VINOD ET AL. receptor-mediated signal transduction pathway that has been implicated in conferring resistance to conventional chemotherapy....
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4,275 citations
"Phytochemicals As Chemosensitizers:..." refers background in this paper
...Curcumin Vinblastine Cervical, breast Yes In vitro (7) In vivo (0) No In vitro (0) In vivo (0) 5-flurocytosine Colon cancer Yes In vitro (2) In vivo (0) No In vitro (0) In vivo (0) Mitomycin C Lung, breast, cervical Yes In vitro (5) In vivo (3) No In vitro (0) In vivo (0) Bortezomib Multiple myeloma Yes In vitro (5) In vivo (1) No In vitro (0) In vivo (0) Thalidomide Multiple myeloma Yes In vitro (1) In vivo (1) No In vitro (0) In vivo (0) Gemcitabine Pancreatic, bladder, prostate Yes In vitro (3) In vivo (2) No In vitro (0) In vivo (0) BCG Bladder Yes In vitro (1) In vivo (1) No In vitro (0) In vivo (0) Paclitaxel Bladder, ovarian, prostate, cervical, breast Yes In vitro (7) In vivo (5) No In vitro (1) In vivo (0) Docetaxel Lung, breast, ovarian Yes In vitro (2) In vivo (5) No In vitro (1) In vivo (0) TRAIL Bladder, prostate, renal, ovarian Yes In vitro (8) In vivo (1) No In vitro (0) In vivo (0) Etoposide Gastric, Glioma, cervical, breast Yes In vitro (5) In vivo (1) No In vitro (0) In vivo (0) Cisplatin Lung, HNSCC, ovarian, breast, fibrosarcoma, glioma, esophageal, neuroblastoma, hepatic Yes In vitro (12) In vivo (0) No In vitro (0) In vivo (0) Doxorubicin Gastric, breast, leukemia, glioma, lung, neuroblastoma, hepatic, leukemia, osteosarcoma, uterine sarcoma, laryngeal Yes In vitro (19) In vivo (1) No In vitro (2) In vivo (0) 5-FU Prostate, colon, esophageal, pancreatic, gastric Yes In vitro (12) In vivo (2) No In vitro (0) In vivo (0) Oxaliplatin Colon cancer Yes In vitro (6) In vivo (0) No In vitro (0) In vivo (0) Dasatinib Colorectal cancer Yes In vitro (2)...
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...Cisplatin Gallbladder cancer, lung cancer, prostate cancer, Merkel cell carcinoma Yes In vitro (5) In vivo (1) No In vitro (1) In vivo (0) Carboplatin Gallbladder cancer, ovarian cancer Yes In vitro (1) In vivo (0) No In vitro (1) In vivo (0) Oxaliplatin Gallbladder cancer Yes In vitro (1) In vivo (0) No In vitro (0) In vivo (0) 5-FU Melanoma, lung cancer, Merkel cell carcinoma Yes In vitro (3) In vivo (0) No In vitro (0) In vivo (0) Mitomycin C Lung cancer Yes In vitro (1) In vivo (0) No In vitro (0) In vivo (0) Gefitinib Lung cancer Yes In vitro (1) In vivo (0) No In vitro (0) In vivo (0) TRAIL Hepatic cancer, cervical cancer Yes In vitro (1) In vivo (0) No In vitro (0) In vivo (0) Arsenic trioxide Leukemia, cervical cancer, gastric carcinoma, oesophageal carcinoma Yes In vitro (6) In vivo (1) No In vitro (0) In vivo (0) Paclitaxel Ovarian cancer, breast cancer, melanoma Yes In vitro (2) In vivo (1) No In vitro (1) In vivo (0) Doxorubicin Merkel cell carcinoma, lung cancer Yes In vitro (2) In vivo (0) No In vitro (1) In vivo (0) Etoposide Lung cancer Yes In vitro (1) In vivo (0) No In vitro (0) In vivo (0) Celecoxib Cholangiocarcinoma Yes In vitro (1) In vivo (0) No In vitro (0) In vivo (0)...
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...Resveratrol TRAIL Colon, neuroblastoma, medulloblastoma, glioblastoma, melanoma, breast, prostate, pancreatic, leukemia Yes In vitro (10) In vivo (1) No In vitro (0) In vivo (0) 5-FU Cholangiocarcinoma, liver cancer, colon, neuroblastoma Yes In vitro (6) In vivo (2) No In vitro (1) In vivo (0) Paclitaxel Lung, nasopharyngeal, epidermoid, leukemia, non-Hodgkin’s lymphoma, multiple myeloma Yes In vitro (6) In vivo (0) No In vitro (6) In vivo (1) Doxorubicin Leukemia, ovarian, uterine, breast, cervical, liver Yes In vitro (7) In vivo (0)...
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...Quercetin Doxorubicin Breast, neuroblastoma, leukemia, melanoma, colon Yes In vitro (8) In vivo (3) No In vitro (3) In vivo (0) TRAIL Lung, prostate, hepatocellular carcinoma, colon, leukemia, glioma, non-Hodgkin’s lymphoma, Yes In vitro (10) In vivo (0) No In vitro (1) In vivo (0) Temozolomide/DTIC Astrocytoma, melanoma Yes In vitro (4) In vivo (0) No In vitro (6) In vivo (1) Paclitaxel Hepatoma, colon, breast Yes In vitro (1) In vivo (1) No In vitro (2) In vivo (0) Cisplatin Colon, HNSCC, ovarian, leukemia, Ewing’s tumor Yes In vitro (6) In vivo (0) No In vitro (0) In vivo (0) Bortezomib Leukemia, multiple myeloma, melanoma Yes In vitro (0) In vivo (0) No In vitro (3) In vivo (0) Etoposide Colon carcinoma, Ewing’s tumor Yes In vitro (3) In vivo (3) No In vitro (0) In vivo (0) Vincristine Breast cancer Yes In vitro (1) In vivo (1) No In vitro (0) In vivo (0)...
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...Curcumin formulations in liposomes, micelles, and phospholipid complexes as well as a combination of curcumin with low doses of piperine (the black pepper alkaloid) have also provided promising results (6)....
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2,235 citations
2,219 citations
"Phytochemicals As Chemosensitizers:..." refers background in this paper
...The NF-jB pathway, activated by different signaling events, is one of the major down-stream effector pathways regulating ROS signaling, leading to chemoresistance (204)....
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1,948 citations
"Phytochemicals As Chemosensitizers:..." refers background in this paper
...and a detailed account of the same is reviewed elsewhere (112)....
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