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Phytopharmacological Investigations of Piper retrofractum Vahl. – A Review

TL;DR: There are only a few studies done to investigate the plant phytochemicals, thus further studies should be focused on isolation and identification of active compounds with pharmacological activities, and further studies are needed to investigate bioactivity of other parts of the plant.
Abstract: Piper retrofractum Vahl. which belongs to the family Piperaceae, is a popular spice possessing high medicinal properties. The present article aims to provide a review of the studies done on phytochemistry and biological activities of P. retrofractum. This review is based on a literature study of scientific journals from electronic sources, such as Science Direct, PubMed, Google Scholar, Scopus, and Web of Science. The main chemical constituents that have been isolated and identified from P. retrofractum are amides, alkaloids, phenylpropanoids, alkyl glycosides, and lignans. This plant possesses antioxidant, hepatoprotective, cytotoxic, larvicidal, antiproliferation, antitubercular, antileishmanial, antiphotoaging, and antiobesity properties. P. retrofractum has the potential for the treatment of several diseases and disorders, but there are only a few studies done to investigate the plant phytochemicals, thus further studies should be focused on isolation and identification of active compounds with pharmacological activities. Besides, the majority of pharmacological studies have been performed using aerial parts of the plant, however, further studies are needed to investigate bioactivity of other parts of the plant.

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Citations
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Journal ArticleDOI
01 Dec 2022-Heliyon
TL;DR: In this paper , film seed coatings with various concentrations of hexane extracts were made for mung bean (Vigna radiata) and corn (Zea mays) seeds.

1 citations

References
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Book
01 Jan 1956

5,524 citations


"Phytopharmacological Investigations..." refers background in this paper

  • ...The seeds are subglobose to obovoid-globose, 2 to 2.5 mm long (Chopra et al., 1986)....

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Book
01 Jan 1992

172 citations


"Phytopharmacological Investigations..." refers background in this paper

  • ...In Thailand, this plant has been categorized nationally as an essential drug for the treatment of the gastrointestinal system, while the fruit is useful for treating bronchitis, bronchial asthma, and muscle pain (Farnsworth and Bunyapraphatsara, 1992)....

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Journal ArticleDOI
TL;DR: The n-hexane, ethyl acetate, methanol, and acetone extracts of Piper cubeba Linn and P. retrofractum were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 μg/ml.
Abstract: The n-hexane, ethyl acetate, methanol, and acetone extracts of Piper cubeba Linn. and P. retrofractum Vahl. (Piperaceae) were evaluated in vitro against promastigotes of Leishmania donovani, and all exhibited significant in vitro activity at 100 μg/ml. Two lignans, cubebin and hinokinin, were isolated from the hexane extract of P. cubeba; and one bis-epoxy lignan, (−)-sesamin, and two amides, pellitorine and piplartine, were isolated from the hexane and methanol extracts of P. retrofractum. Cubebin and piplartine showed significant antileishmanial activity in vitro at 100 μM and were further tested in vivo in a hamster model of visceral leishmaniasis. Piplartine showed activity at 30 mg/kg dose. This is the first report of antileishmanial activity of these two plants and their isolated constituents.

96 citations


"Phytopharmacological Investigations..." refers background in this paper

  • ...Pellitorine Stems Bodiwala et al., 2007 Fruits Muharini et al., 2015 Fruits Kikuzaki et al., 1993 Piplartine Stems Bodiwala et al., 2007 Piperodione Fruits Kubo et al., 2013 (2E,12E)-pipertridecadienamide Fruits Kubo et al., 2013 N-isobutyl-(2E,4E,10Z)-hexadeca-2,4,10-trienamide Fruits Kubo et al.,…...

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  • ...…(besides volatile constituents) have been reported including seventy-seven amides (Banerji et al., 1985; Ahn et al., 1992; Kikuzaki et al., 1993; Bodiwala et al., 2007; Kubo et al., 2013; Muharini et al., 2015; Amad et al, 2017; Tang et al., 2019), four amide glycosides (Tang et al., 2019),…...

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  • ...Up to now, 97 compounds (besides volatile constituents) have been reported including seventy-seven amides (Banerji et al., 1985; Ahn et al., 1992; Kikuzaki et al., 1993; Bodiwala et al., 2007; Kubo et al., 2013; Muharini et al., 2015; Amad et al, 2017; Tang et al., 2019), four amide glycosides (Tang et al....

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  • ...However, (-)-sesamin was found inactive (Bodiwala et al., 2007)....

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  • ...Pellitorine Stems Bodiwala et al., 2007 Fruits Muharini et al., 2015 Fruits Kikuzaki et al., 1993 Piplartine Stems Bodiwala et al., 2007 Piperodione Fruits Kubo et al., 2013 (2E,12E)-pipertridecadienamide Fruits Kubo et al., 2013 N-isobutyl-(2E,4E,10Z)-hexadeca-2,4,10-trienamide Fruits Kubo et al., 2013 Isopiperine Fruits Kubo et al., 2013 Isochavicine Fruits Kubo et al., 2013 5,6-Dihydropiperlongmine Fruits Kubo et al., 2013 5,6-Dihydro-1H-pyridin-2-one Fruits Tang et al., 2019 cis-Fragaramide Fruits Kubo et al., 2013 trans-Fragaramine Fruits Kubo et al., 2013 Fruits Tang et al., 2019 N-isobutyl-(2E,4E,12Z)-octadeca-2,4,12-trienamide Fruits Tang et al., 2019 N-isobutyl-(2E,4E,12Z)-hexadeca-2,4,12-trienamide Fruits Kubo et al., 2013 N-isobutyl-(2E,4E)-hexadeca-2,4-dienamide Fruits Kubo et al., 2013 (2E,4Z,8E)-N-[(3,4-methylendioxy-phenyl)-2,4,8-nonatrienoyl]piperidine Fruits Kubo et al., 2013 N-Cinnamoylpiperidine Fruits Kubo et al., 2013 Piperoleine B Fruits Kubo et al., 2013 Fruits Tang et al., 2019 Piperchabamide B Fruits Kubo et al., 2013 Fruits Tang et al., 2019 Piperchabamide C Fruits Kubo et al., 2013 Fruits Muharini et al., 2015 Piperchabamide H Fruits Kubo et al., 2013 Fruits Muharini et al., 2015 Piperundecaline Fruits Kubo et al., 2013 Fruits Muharini et al., 2015 Dehydropipernonaline Fruits Kubo et al., 2013 Fruits Muharini et al., 2015 Pipernonaline Fruits Kubo et al., 2013 Fruits Muharini et al., 2015 Fruits Ahn et al., 1992 Fruits Tang et al., 2019 N-isobutyl-2E,4E,12Z-octadecatrienamide Fruits Kikuzaki et al., 1993 Agric. conspec. sci. Vol. 85 (2020) No. 3 aCS...

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Journal Article
TL;DR: Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatus Say and Aedes aegypt (L.) and the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae.
Abstract: Aqueous extracts of nine medicinal plants were bioassayed against larvae of Culex quinquefasciatus Say and Aedes aegypt (L.). Among these plants, the long pepper, Piper retrofractum Vahl (Piperaceae), showed the highest level of activity against mosquito larvae. To gain more information on larvicidal activity of P. retrofractum, fresh fruits of this plant were extracted in water and the extracts made into powder and bioassayed against 3rd and 4th instar larvae of Cx. quinquefasciatus and Ae. aegypti in the laboratory. Extracts of unripe (001/3) and ripe (002/3 and 001/4) fruits showed different levels of activity against Cx. quinquefasciatus larvae. Extracts 001/3 and 002/3 were equi-toxic to a Bacillus sphaericus resistant and susceptible strains, both from Thailand. The ripe fruit extract 002/3 was somewhat more active against Ae. aegypti than Cx. quinquefasciatus. Another ripe fruit extract (001/4) was much more toxic to both mosquito species. Diluted solutions of the solid extract (002/3) in distilled water lost their larvicidal activity upon aging. Loss of activity at 25 degrees C was greater than that stored at 4 degrees C, and greater in water than in acetone solution.

94 citations


"Phytopharmacological Investigations..." refers background in this paper

  • ...…et al., 2017; Mahaldar et al., 2019), hepatoprotective (Mahaldar et al., 2019), cytotoxic (Amad et al., 2017; Ekowati et al., 2012), larvicidal (Chansang et al., 2005), antiproliferation (Hasan et al., 2016), antitubercular (Amad et al., 2017), antileishmanial (Bodiwala et al., 2007),…...

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  • ...Chansang et al. (2005) reported the mosquito larvicidal activity of the fresh fruits water extract....

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Journal ArticleDOI
TL;DR: It is demonstrated that PRPAs attenuate HFD-induced obesity by activating AMPK and PPARδ, and regulate lipid metabolism, suggesting their potential anti-obesity effects.

93 citations


"Phytopharmacological Investigations..." refers background in this paper

  • ...…et al., 2012), larvicidal (Chansang et al., 2005), antiproliferation (Hasan et al., 2016), antitubercular (Amad et al., 2017), antileishmanial (Bodiwala et al., 2007), antiphotoaging (Yun et al., 2018), and anti-obesity (Kim et al., 2011) activities, have been reported in several research articles....

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  • ...Anti-obesity activity Kim et al. (2011) evaluated the anti-obesity effects of P. retrofractum in high-fat diet (HFD)-induced obese mice....

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Trending Questions (3)
What are the mechanisms of action of Piper retrofractum in regulating fertility in vitro?

The provided paper does not mention the mechanisms of action of Piper retrofractum in regulating fertility in vitro.

What is the ligand of Piper retrofractum?

The paper does not provide information about the specific ligand of Piper retrofractum.

How to analyze the constituents of Piper retrofractum?

The constituents of Piper retrofractum can be analyzed through phytochemical studies and isolation of active compounds.