PI3K signaling in cancer: beyond AKT.
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TLDR
Three PI3K-dependent, but AKT-independent, signaling branches that have recently been shown to have important roles in promoting phenotypes associated with malignancy are highlighted.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2017-04-01 and is currently open access. It has received 330 citations till now. The article focuses on the topics: Autocrine signalling & PI3K/AKT/mTOR pathway.read more
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Journal ArticleDOI
AKT/PKB Signaling: Navigating the Network
Brendan D. Manning,Alex Toker +1 more
TL;DR: Improved understanding of the molecular wiring of the AKT signaling network continues to make an impact that cuts across most disciplines of the biomedical sciences.
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The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism.
TL;DR: The role of quercetin in cancer metabolism is discussed, addressing specifically its ability to target molecular pathways involved in glucose metabolism and mitochondrial function.
Journal ArticleDOI
PI3K isoforms in cell signalling and vesicle trafficking.
TL;DR: Current knowledge of the different PI3K classes and isoforms is summarized, focusing on recently uncovered biological functions and the mechanisms by which these kinases are activated.
Journal ArticleDOI
Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma.
Christian Grommes,Christian Grommes,Alessandro Pastore,Nicolaos Palaskas,Sarah S. Tang,Carl Campos,Derrek Schartz,Paolo Codega,Donna Nichol,Owen Clark,Wan-Ying Hsieh,Daniel Rohle,Marc K. Rosenblum,Agnes Viale,Viviane Tabar,Cameron Brennan,I. T. Gavrilovic,I. T. Gavrilovic,Thomas Kaley,Thomas Kaley,Craig Nolan,Craig Nolan,Antonio M. P. Omuro,Antonio M. P. Omuro,Elena Pentsova,Elena Pentsova,Alissa A. Thomas,Elina Tsyvkin,Elina Tsyvkin,Ariela Noy,Ariela Noy,M. Lia Palomba,M. Lia Palomba,Paul A. Hamlin,Paul A. Hamlin,Craig S. Sauter,Craig S. Sauter,Craig H. Moskowitz,Craig H. Moskowitz,Julia Wolfe,Ahmet Dogan,Minhee Won,Jon Glass,Scott Peak,Enrico C. Lallana,Vaios Hatzoglou,Anne S. Reiner,Philip H. Gutin,Jason T. Huse,Katherine S. Panageas,Thomas G. Graeber,Nikolaus Schultz,Lisa M. DeAngelis,Lisa M. DeAngelis,Ingo K. Mellinghoff,Ingo K. Mellinghoff +55 more
TL;DR: Ibrutinib has substantial activity in patients with relapsed or refractory B-cell lymphoma of the CNS, and combined inhibition of BTK and PI3K/mTOR may augment the ibrut inib response in CD79B-mutant human PCNSLs.
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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.
TL;DR: This review outlines the emerging diversity of the genetic alterations that lead to activated PI3K-AKT-mTOR signaling in prostate cancer, and discusses new mechanistic insights into the interplay between the PI3k-AKt- mTOR pathway and several key interacting oncogenic signaling cascades that can cooperate to facilitate prostate cancer growth and drug-resistance.
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