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Pillars article: approaching the asymptote? Evolution and revolution in immunology. Cold spring harb symp quant biol. 1989. 54: 1-13.
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This article is published in Journal of Immunology.The article was published on 2013-11-01 and is currently open access. It has received 223 citations till now.read more
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DNA sensing by the cGAS–STING pathway in health and disease
TL;DR: The cGAS–STING pathway forms a major DNA-sensing mechanism in mammalian cells and emerging evidence of its role in monogenic inflammatory diseases and cancer and new therapeutic opportunities is highlighted.
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Intrinsic antiviral immunity
Nan Yan,Zhijian J. Chen +1 more
TL;DR: This review focuses on recent advances in understanding of the roles of intrinsic antiviral factors that restrict infection by human immunodeficiency virus and influenza virus.
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Nanoparticle hydrophobicity dictates immune response.
Daniel F. Moyano,Meir Goldsmith,David J. Solfiell,Dalit Landesman-Milo,Oscar R. Miranda,Dan Peer,Vincent M. Rotello +6 more
TL;DR: Empirically engineered gold nanoparticles were used to determine the sole effect of hydrophobicity on the immune response of splenocytes, with an essentially linear increase in immune activity with the increase in hydrophOBicity observed in vitro.
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The Drosophila Imd Signaling Pathway
TL;DR: The current literature on the Drosophila Imd pathway is reviewed, with special emphasis on its role in the (patho)physiology of different organs, and the systemic response, as well as local responses, in the epithelial and mucosal surfaces and the nervous system are discussed.
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Pattern Recognition Receptors and the Host Cell Death Molecular Machinery
Gustavo P. Amarante-Mendes,Sandy Adjemian,Laura Migliari Branco,Larissa C. Zanetti,Ricardo Weinlich,Karina R. Bortoluci +5 more
TL;DR: Some aspects of the molecular interplay between the cell death machinery and signals initiated by the activation of PRRs by PAMPs and DAMPs are discussed.