PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease
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Cites background from "PINK1-induced mitophagy promotes ne..."
...counteract mitophagy impairment and neurotoxicity in a Drosophila model of Huntington disease.(65) In light of these findings, the localization of PINK1, PARK2 and BECN1 in the MAM compartment opens a novel intriguing scenario to further explore the biological functions of these pivotal neuroprotective proteins....
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Cites background from "PINK1-induced mitophagy promotes ne..."
...The overexpression of PINK1 alleviated defective mitophagy and ameliorated neuronal integrity, ATP levels as well as adult fly survival, suggesting that PINK confers neuroprotection against mutant huntingtin in flies [165]....
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...It has also been demonstrated that mutant huntingtin transcriptionally represses PGC1α in mice, thereby inhibiting mitochondrial biogenesis [164] and impairs mitophagy in Drosophila neurons by reducing the targeting of damaged mitochondria to autophagosomes [165]....
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"PINK1-induced mitophagy promotes ne..." refers background in this paper
...Mammalian VDAC1 was identified as a target for Parkin-mediated ubiquitination and to promote mitophagy in HeLa cells.(16) In contrast, while ubiquitination of VDAC1 was confirmed in MEF cells with damaged mitochondria, VDAC1 appeared dispensable for mitochondrial clustering and mitophagy in those cells....
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...It has been proposed that voltage-dependent anion channel (VDAC) could be part of the PINK1/Parkin pathway.(16,17) As...
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"PINK1-induced mitophagy promotes ne..." refers background in this paper
...The impact of PINK1 homozygosity was not tested, as Drosophila carrying two PINK1 mutant alleles already show decreased lifespan.(13) We next monitored ATP levels to evaluate mitochondrial function....
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1,440 citations