Pipeline for uncoilable or failed aneurysms: results from a multicenter clinical trial.
Tibor Becske,David F. Kallmes,Isil Saatci,Cameron G. McDougall,István Szikora,Giuseppe Lanzino,Christopher J. Moran,Henry H. Woo,Demetrius K. Lopes,Aaron L. Berez,Daniel J. Cher,Adnan H. Siddiqui,Elad I. Levy,Felipe C. Albuquerque,David Fiorella,Zsolt Berentei,Miklos G. Marosfoi,Saruhan Cekirge,Peter Kim Nelson +18 more
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TLDR
PED offers a reasonably safe and effective treatment of large or giant intracranial internal carotid artery aneurysms, demonstrated by high rates of completeAneurysm occlusion and low rates of adverse neurologic events; even in aneurYSms failing previous alternative treatments.Abstract:
The Pipeline for Uncoilable or Failed Aneurysms study demonstrated a high rate (78 of 108, 73.6%) of complete occlusion of large and giant wide-necked aneurysms of the internal carotid artery and a reasonably low rate of major safety events (6 of 107, 5.6% rate of major stroke or neurologic death).read more
Citations
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Journal ArticleDOI
Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
B. Gregory Thompson,Robert D. Brown,Sepideh Amin-Hanjani,Joseph P. Broderick,Kevin M. Cockroft,E. Sander Connolly,Gary Duckwiler,Catherine Harris,Virginia J. Howard,S. Claiborne Johnston,Philip M. Meyers,Andrew J. Molyneux,Christopher S. Ogilvy,Andrew J. Ringer,James C. Torner +14 more
TL;DR: This updated statement provides comprehensive and evidence-based recommendations for management of patients with unruptured intracranial aneurysms and addresses presentation, natural history, epidemiology, risk factors, screening, diagnosis, imaging and outcomes from surgical and endovascular treatment.
Journal ArticleDOI
Long-Term Clinical and Angiographic Outcomes Following Pipeline Embolization Device Treatment of Complex Internal Carotid Artery Aneurysms: Five-Year Results of the Pipeline for Uncoilable or Failed Aneurysms Trial
Tibor Becske,Waleed Brinjikji,Matthew B. Potts,David F. Kallmes,Maksim Shapiro,Christopher J. Moran,Elad I. Levy,Cameron G. McDougall,István Szikora,Giuseppe Lanzino,Henry H. Woo,Demetrius K. Lopes,Adnan H. Siddiqui,Felipe C. Albuquerque,David Fiorella,Isil Saatci,Saruhan Cekirge,Aaron L. Berez,Daniel J. Cher,Zsolt Berentei,Miklos G. Marosfoi,Peter Kim Nelson +21 more
TL;DR: The 5-yr findings demonstrate that PED is a safe and effective treatment for large and giant wide-necked aneurysms of the intracranial ICA, with high rates of complete occlusion and low rates of delayed adverse events.
Journal ArticleDOI
Endovascular treatment of intracranial aneurysms: current status.
Laurent Pierot,Ajay K. Wakhloo +1 more
TL;DR: The randomized International Subarachnoid Aneurysm Trial (ISAT) study has clearly demonstrated the superiority of endovascular treatment (EVT) of ruptured aneurysms using coil technology over surgery.
Journal ArticleDOI
The safety and effectiveness of the Woven EndoBridge (WEB) system for the treatment of wide-necked bifurcation aneurysms: final 12-month results of the pivotal WEB Intrasaccular Therapy (WEB-IT) Study.
Adam S Arthur,Andy Molyneux,Alexander L. Coon,Isil Saatci,István Szikora,Feyyaz Baltacioglu,Ali Sultan,Daniel Hoit,Josser E Delgado Almandoz,Lucas Elijovich,Saru Cekirge,James V. Byrne,David Fiorella +12 more
TL;DR: The results of this trial suggest that the WEB device provides an option for patients with wide-neck bifurcation aneurysms that is as effective as currently available therapies and markedly safer.
Journal ArticleDOI
Comparison of Flow Diversion and Coiling in Large Unruptured Intracranial Saccular Aneurysms
Nohra Chalouhi,Stavropoula Tjoumakaris,Robert M. Starke,L. Fernando Gonzalez,Ciro Randazzo,David Hasan,Jeffrey F. McMahon,Saurabh Singhal,Lea A Moukarzel,Aaron S. Dumont,Robert H. Rosenwasser,Pascal Jabbour +11 more
TL;DR: The PED provides higher aneurysm occlusion rates than coiling, with no additional morbidity and similar clinical outcomes, suggesting that the PED might be a preferred treatment option for large unruptured saccular aneurYSms.
References
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Journal ArticleDOI
Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment
TL;DR: Patients' age was a strong predictor of surgical outcome, and the size and location of an aneurysm predict both surgical and endovascular outcomes.
Journal ArticleDOI
International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion
Andrew J. Molyneux,Richard S. C. Kerr,Ly-Mee Yu,Mike Clarke,Mary Sneade,Julia A. Yarnold,Peter Sandercock +6 more
TL;DR: In patients with ruptured intracranial aneurysms suitable for both treatments, endovascular coiling is more likely to result in independent survival at 1 year than neurosurgical clipping; the survival benefit continues for at least 7 years.
Journal ArticleDOI
Long-Term Angiographic Recurrences After Selective Endovascular Treatment of Aneurysms With Detachable Coils
Jean Raymond,François Guilbert,Alain Weill,Stavros A. Georganos,Louis Juravsky,Anick Lambert,Julie Lamoureux,Miguel Chagnon,Daniel Roy +8 more
TL;DR: Variables determined to be significant predictors of a recurrence included aneurysm size ≥10 mm, treatment during the acute phase of rupture, incomplete initial occlusions, and duration of follow-up, and long-term monitoring of patients treated by endosaccular coiling is mandatory.
Journal ArticleDOI
International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized trial.
Andrew J. Molyneux,Richard S. C. Kerr,Irene M Stratton,Peter Sandercock,Mike Clarke,Julia A Shrimpton,Rury R. Holman +6 more
TL;DR: In patients with a ruptured intracranial aneurysm, for which endovascular coiling and neurosurgical clipping are therapeutic options, the outcome in terms of survival free of disability at 1 year is significantly better with endov vascular coiling.
Journal ArticleDOI
Curative endovascular reconstruction of cerebral aneurysms with the pipeline embolization device: the Buenos Aires experience.
Pedro Lylyk,Carlos Miranda,Rosana Ceratto,Angel Ferrario,Esteban Scrivano,Hugh Ramirez Luna,Aaron L. Berez,Quang Tran,Peter Kim Nelson,David Fiorella +9 more
TL;DR: The Pipeline Embolization Device (PED) as mentioned in this paper is a microcatheter-delivered endovascular construct designed to achieve the curative reconstruction of the parent arteries giving rise to wide-necked and fusiform intracranial aneurysms.
Related Papers (5)
International retrospective study of the pipeline embolization device: a multicenter aneurysm treatment study
David F. Kallmes,Ricardo A. Hanel,Demetrius K. Lopes,Edoardo Boccardi,Alain Bonafe,Saruhan Cekirge,David Fiorella,Pascal Jabbour,Elad I. Levy,Cameron G. McDougall,Adnan H. Siddiqui,István Szikora,Henry H. Woo,Felipe C. Albuquerque,Hormozd Bozorgchami,Shervin R. Dashti,J Delgado Almandoz,Michael Kelly,R. I. Turner,B. K. Woodward,Waleed Brinjikji,Giuseppe Lanzino,Pedro Lylyk +22 more