Piperidine alkaloids from Piper retrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase.
Citations
137 citations
Cites background from "Piperidine alkaloids from Piper ret..."
...…dehydropipernonaline 320 lated from Piper retrofractum, such as piperine, pipernonaline, and dehydropipernonaline, activated AMP-activated protein kinase (AMPK) signaling and the PPAR-γ protein (Kim et al., 2011) in 3T3-L1 adipocytes and L6 myocytes, suggesting potential antidiabetic effects....
[...]
...…juncea (Thirumalai et al., 2011), Salvia officinalis L. (Eidi et al., 2005), Ruta graveolens (Ahmed et al., 2010), Carissa carandas (Itankar et al., 2011), Pinus pinaster (Bedekar et al., 2010; El-Zein et al., 2011), Punica granatum (Bagri et al., 2009), and Piper retrofractum (Kim et al., 2011)....
[...]
...…compounds such as iriflophenone 2-O-αL-rhamnopyranoside, iriflophenone 3-C-β-D-glucoside, iriflophenone-3,5-C-β-D-diglucopyranoside (Feng et al., 2011), eleutherinoside , and eleuthoside (Ieyama et al., 2011); and bromophenols such as 2,4,6-tribromophenol and 2,4-dibromophenol (Kim et al., 2011)....
[...]
...…et al., 2011; Bedekar et al., 2010; Liu et al., 2004 Piper retrofractum fruits piperidine alkaloids: piperine, pipernonaline,dehydropipernonaline 3T3-L1 adipocytes L6 myocytes Ethanol extract Kim et al., 2011 318 decrease in blood glucose levels upon administration of Urtica dioica extracts....
[...]
104 citations
96 citations
Cites background from "Piperidine alkaloids from Piper ret..."
...It has been reported that piperine could activate AMPK signaling and reduce the phosphorylation of ERK (Choi et al., 2013; Hwang et al., 2011; Kim et al., 2011)....
[...]
...AMPKα signaling in mice (Choi et al., 2013; Kim et al., 2011)....
[...]
...Previous studies demonstrated that piperine suppresses the activation of ERK and activates AMPKα (Choi et al., 2013; Hwang et al., 2011; Kim et al., 2011)....
[...]
79 citations
Cites background from "Piperidine alkaloids from Piper ret..."
...In liver and muscle tissue, there is an inverse relationship betweenAMPKandelevation of sterol regulatory element bindingprotein-1c (SREBP-1c) activity (Kim et al., 2011)....
[...]
77 citations
References
5,301 citations
"Piperidine alkaloids from Piper ret..." refers background in this paper
...An elevated plasma concentration of low-density lipoprotein cholesterol (LDL-C) increases the risk of coronary heart disease, and the clinical complications of atherosclerosis could be diminished when plasma lipids are lowered by hypocholesterolemic agents [21]....
[...]
4,002 citations
"Piperidine alkaloids from Piper ret..." refers background in this paper
...Obesity is a chronic metabolic disorder caused by energy imbalance that is characterized by increased fat mass and dysregulated lipid metabolism [1]....
[...]
2,855 citations
1,091 citations
"Piperidine alkaloids from Piper ret..." refers background in this paper
...PPARd is predominantly expressed in liver and skeletal muscle, where they regulate lipid metabolism, and is well known as a fat burning-transcription factor exhibiting an anti-obesity function [7]....
[...]
...PPARd regulates lipid metabolism and is an established fat burning-transcription factor exerting anti-obesity effects [7]....
[...]
...regulation genes such as carnitine palmitoyltransferase-1 (CPT-1), which transfers long-chain fatty acids into the mitochondria, and uncoupling proteins (UCPs), which are involved in energy expenditure through fat burning [7,9]....
[...]
1,084 citations