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Plant-derived natural product research aimed at new drug discovery.
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TLDR
Research on many different useful compounds isolated or developed from plants with emphasis placed on those recently discovered by the authors’ laboratories as antitumor and anti-HIV clinical trial candidates are summarized.Abstract:
Many important bioactive compounds have been discovered from natural sources using bioactivity-directed fractionation and isolation (BDFl) [Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. Life Sci 78:431–441]. Continuing discovery has also been facilitated by the recent development of new bioassay methods. These bioactive compounds are mostly plant secondary metabolites, and many naturally occurring pure compounds have become medicines, dietary supplements, and other useful commercial products. Active lead compounds can also be further modified to enhance the biological profiles and developed as clinical trial candidates. In this review, the authors will summarize research on many different useful compounds isolated or developed from plants with emphasis placed on those recently discovered by the authors’ laboratories as antitumor and anti-HIV clinical trial candidates.read more
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Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis.
TL;DR: The potential molecular targets and signaling pathways that mediate tumor onset and metastasis are discussed and some of the phytochemicals capable of targeting these signaling pathways which would make them potentially applicable to cancer chemoprevention, treatment and control of cancer progression are shed light.
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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemia and antitumor agent from
M. C. Wani,H. E. A. Taylor +1 more
Journal ArticleDOI
Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids
Alaíde Braga de Oliveira,Maria Fâni Dolabela,Maria Fâni Dolabela,Fernão Castro Braga,Rose Lisieux R. Paiva Jácome,Fernando de Pilla Varotti,Marinete Marins Póvoa +6 more
TL;DR: This review discusses these two approaches, presents briefly the screening methodologies for evaluation of antimalarial activity and focuses the activity of alkaloids belonging to different structural classes as well as its importance as new antimalaria drugs or leads and chemical markers for phytomedicines.
Journal ArticleDOI
Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis
TL;DR: Antitumor compounds produced by actinomycetes and novel derivatives generated by combinatorial biosynthesis are reviewed and a description of the strategies used for the generation of the novel derivatives and the activities of these compounds against tumor cell lines is described.
References
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Journal ArticleDOI
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
Journal Article
Anticancer potential of curcumin: preclinical and clinical studies.
TL;DR: Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.
Journal ArticleDOI
Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2
Journal ArticleDOI
Curcumin: Getting Back to the Roots
TL;DR: Interestingly, 6‐gingerol, a natural analog of curcumin derived from the root of ginger (Zingiber officinalis), exhibits a biologic activity profile similar to that ofCurcumin, which is now being used to treat cancer, arthritis, diabetes, Crohn's Disease, cardiovascular diseases, osteoporosis, Alzheimer's disease, psoriasis, and other pathologies.
Journal ArticleDOI
Identification of an antimalarial synthetic trioxolane drug development candidate.
Jonathan L. Vennerstrom,Sarah Arbe-Barnes,Reto Brun,Susan A. Charman,Francis C. K. Chiu,Jacques Chollet,Yuxiang Dong,Arnulf Dorn,Daniel Hunziker,Hugues Matile,Kylie Anne McIntosh,Maniyan Padmanilayam,Josefina Santo Tomas,Christian Scheurer,Bernard Scorneaux,Yuanqing Tang,Heinrich Urwyler,Sergio Wittlin,William N. Charman +18 more
TL;DR: Here it is described how a synthetic peroxide antimalarial drug development candidate was identified in a collaborative drug discovery project.
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