Journal ArticleDOI
Plant natural products active against snake bite--the molecular approach.
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From the evidence presented, it can be inferred that micromolecules which neutralize the action of snake venoms mechanistically replace endogenous antitoxic serum proteins with venom neutralizing capacity such as produced by some animals.About:
This article is published in Phytochemistry.The article was published on 2000-11-01. It has received 325 citations till now. The article focuses on the topics: Bothrops jararaca.read more
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The magic glue hyaluronan and its eraser hyaluronidase: a biological overview.
TL;DR: Inhibition of HA degradation therefore may be crucial in reducing disease progression and spread of venom/toxins and bacterial pathogens, and potent, ubiquitous regulating agents that are involved in maintaining the balance between the anabolism and catabolism of HA.
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Structural characterization of flavonoid glycosides by multi-stage mass spectrometry.
Viktoria Vukics,András Guttman +1 more
TL;DR: This review summarizes and compares currently available methods for structural elucidation of flavonoids by LC-MS andLC-MS(n), and focuses on the identification options of unknown flavonoid glycosides in complex samples with the emphasis on the differentiation of isomeric compounds.
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Ethnobotanical survey of folk plants for the treatment of snakebites in Southern part of Tamilnadu, India.
TL;DR: Protective activity of plants-Aristolochia indica, Hemidesmus indicus, Gloriosa superba, Strychnos nux-vomica, Eclipta prostrata, and Andrographis paniculata against the lethal action of snake venom and need further investigation.
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Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2—A global assessment based on bibliographic sources
Michael Heinrich,Jennifer A. Chan,Stefan Wanke,Christoph Neinhuis,Monique S. J. Simmonds,Monique S. J. Simmonds +5 more
TL;DR: An extensive review of the scientific literature available on the local and traditional use of Aristolochia spp.
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Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction
Fábio Kiss Ticli,Hage Li,R. S. Cambraia,Paulo Pereira,Angelo J. Magro,Marcos R.M. Fontes,Rodrigo G. Stábeli,Giglio,Suzelei C. França,Andreimar M. Soares,Suely Vilela Sampaio +10 more
TL;DR: The pure compound potentiated the ability of the commercial equine polyvalent antivenom in neutralizing lethal and myotoxic effects of the crude venom and of isolated PLA2s in experimental models.
References
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Medicinal and Poisonous Plants of Southern and Eastern Africa@@@The Medicinal and Poisonous Plants of Southern and Eastern Africa
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Pharmacology of Curcuma longa
TL;DR: It appears that when given orally, curcumin is far less active than after i.p. administration, and systemic effects seem to be questionable after oral application except that they occur at very low concentrations ofCurcumin, which does not exclude a local action in the gastrointestinal tract.
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Flavonoids, a class of natural products of high pharmacological potency
TL;DR: The few existing reports on the careful pharmacodynamic, pharmacokinetic and clinical studies which have been made have been summarized to provide a basis for a full-scale investigation of the therapeutic potential of flavonoids.
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Cholesterol and the cell membrane.
TL;DR: Recent studies concerning cholesterol, its behavior and its roles in cell growth provide important new clues to the role of this fascinating molecule in normal and pathological states.