Plasma renin level in hepatic cirrhosis. Relaton to functional renal failure.
TL;DR: In this paper, the renin levels were measured in twenty-four patients with cirrhosis and ascites, including seven with unexplained renal failure, and a significant correlation between renin and glomerular filtration rate was found.
About: This article is published in The American Journal of Medicine.The article was published on 1970-08-01. It has received 103 citations till now. The article focuses on the topics: Plasma renin activity & Effective renal plasma flow.
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1,530 citations
TL;DR: The role of the kidney in blood-pressure regulation was established by TIGERSTEDT and Bergman at the close of the 19th century as discussed by the authors, who produced hypertension in dogs by injecting a cr...
Abstract: TIGERSTEDT and Bergman established a role for the kidney in blood-pressure regulation at the close of the 19th century. In a classic experiment, they produced hypertension in dogs by injecting a cr...
278 citations
TL;DR: The degree of stimulation of the renin-angiotensin-aldosterone system in cirrhosis is related to abnormalities in the hepatic hemodynamics, and a close direct correlation was observed between the wedged hepatic vein pressure and plasma renin concentration and activity.
236 citations
TL;DR: Three patients with progressive renal failure and advanced hepatic insufficiency due to cirrhosis of the liver underwent orthotopic liver transplantation, and within two weeks after liver replacement regained nearly normal kidney function.
Abstract: Three patients with progressive renal failure and advanced hepatic insufficiency due to cirrhosis of the liver underwent orthotopic liver transplantation. All three patients had immediate improvement in hepatic function and within two weeks after liver replacement regained nearly normal kidney function. However, the renal recovery was delayed in each case, and its course was not uniform. Plasma renin activity was high, and renin substrate was low before transplantation in one case in which these measurements were obtained; both returned to normal soon after liver replacement. (N Engl J Med 289:1155–1159, 1973)
232 citations
TL;DR: Effective treatments of HRS (vasoconstrictors associated with intravenous albumin, transjugular intrahepatic portacaval shunt, albumin dialysis) that can improve survival have recently been introduced.
Abstract: Hepatorenal syndrome (HRS) is a functional renal failure that frequently develops in patients with advanced cirrhosis and severe impairment in systemic circulatory function Traditionally it has been considered to be the consequence of a progression of the splanchnic arterial vasodilation occurring in these patients However, recent data indicate that a reduction in cardiac output also plays a significant role There are two different types of HRS Type-2 HRS consists of a moderate and steady or slowly progressive renal failure It represents the extreme expression of the circulatory dysfunction that spontaneously develops in patients with cirrhosis The main clinical problem in these patients is refractory ascites Type-1 HRS is a rapidly progressive acute renal failure that frequently develops in closed temporal relationship with a precipitating event, commonly spontaneous bacterial peritonitis In addition to renal failure, patients with type-1 HRS present deterioration in the function of other organs, including the heart, brain, liver, and adrenal glands Type-1 HRS is the complication of cirrhosis associated with the worst prognosis However, effective treatments of HRS (vasoconstrictors associated with intravenous albumin, transjugular intrahepatic portacaval shunt, albumin dialysis) that can improve survival have recently been introduced
180 citations
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TL;DR: Substantially substituted derivatives of hippuric acid which could be determined by appropriate coupling reactions were prepared and studied under conditions permitting the exact comparison of renal clearances with those of diodrast atnd hippuran.
Abstract: The efficiency with which diodrast (3, 5-diiodo-4-pyridone-1-acetic acid) and hippuran (oiodohippuric acid) are excreted by the renal tubules (1, 2) raises the question to what extent the organically-bound iodine in these molecules is responsible for the phenomenon of tubular excretion. Since suitable quantitative methods for the determination of unsubstituted compounds wvere not available, substituted derivatives of hippuric acid which could be determined by appropriate coupling reactions were prepared 2 and studied under conditions permitting the exact comparison of renal clearances with those of diodrast atnd hippuran. Methods of comparing clearances. When two substances, both of which are excreted by the tubules, are presented to the tubular excretory mechanism simultaneously, one substance may depress the tubular excretion of the other (2, 3).3 Consequently, in the absence of information to
1,544 citations
868 citations
TL;DR: Theories Proposed for Control of Renin Release and the role of angiotensin are proposed.
Abstract: Theories Proposed for Control of Renin Release. 359 Introduction. 359 Baroreceptor theory. 361 Macula densa theory. 362 Sympathetic nervous system theory. 366 Hormonal control of renin release and role of angiotensin. 367 Analysis of Renin Release Data. 368 Introduction. 368 Methodological considerations. 368 Hemorrhage and systemic hypotension. 369 Acute local reduction of renal arterial pressure during oliguria or natriuresis ... 370 Acute sodium depletion by natriuretic drugs. 371
492 citations