Journal ArticleDOI
Plasmids and the spread of resistance
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TLDR
The characteristics of the most successful plasmids that were at the origin of the spread of carbapenemase, expanded-spectrum β-lactamase, and plasmid-mediated quinolone resistance genes are discussed in this review.About:
This article is published in International Journal of Medical Microbiology.The article was published on 2013-08-01. It has received 731 citations till now. The article focuses on the topics: Plasmid & Horizontal gene transfer.read more
Citations
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Journal ArticleDOI
Mobile Genetic Elements Associated with Antimicrobial Resistance
TL;DR: The characteristics of the major types of mobile genetic elements involved in acquisition and spread of antibiotic resistance in both Gram-negative and Gram-positive bacteria are outlined, focusing on the so-called ESKAPEE group of organisms, which have become the most problematic hospital pathogens.
Journal ArticleDOI
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
TL;DR: This article highlights the recent progress obtained for organisms of clinical significance, together with methodological considerations for the characterization of MDR pumps, with particular focus on AcrAB-TolC and Mex pumps.
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Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer.
Christian J. H. von Wintersdorff,John Penders,Julius M. van Niekerk,Nathan D. Mills,Snehali Majumder,Lieke B. van Alphen,Paul H. M. Savelkoul,Paul H. M. Savelkoul,Petra F. G. Wolffs +8 more
TL;DR: The concept of the resistome is discussed, examples of HGT of clinically relevant ARGs are provided and an overview of the current knowledge of the contributions the various HGT mechanisms make to the spread of antibiotic resistance is presented.
Journal ArticleDOI
Mechanism of quinolone action and resistance.
TL;DR: This review describes the development of the quinolones as antibacterials, the structure and function of gyrase and topoisomerase IV, and the mechanistic basis for quInolone action against their enzyme targets, and suggests approaches to designing new drugs that display improved activity against resistant strains.
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The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae
TL;DR: Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in the 2000s as important human pathogens, have spread extensively throughout the world, and are responsible for the rapid increase in antimicrobial resistance among E. coli and K. pneumoniae strains.
References
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Journal ArticleDOI
Extended-spectrum beta-lactamases: a clinical update.
TL;DR: Extended-spectrum β-lactamases represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents.
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Identification of plasmids by PCR-based replicon typing
Alessandra Carattoli,Alessia Bertini,Laura Villa,Vincenzo Falbo,Katie L. Hopkins,E. John Threlfall +5 more
TL;DR: Results indicated that the inc/rep PCR method demonstrates high specificity and sensitivity in detecting replicons on reference plasmids and also revealed the presence of recurrent and common plasmid in epidemiologically unrelated Salmonella isolates of different serotypes.
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Mechanisms of, and Barriers to, Horizontal Gene Transfer between Bacteria
TL;DR: If a gene moves onto a broad-host-range plasmid it might be able to spread without the need for recombination, and there are barriers to both these processes but they reduce, rather than prevent, gene acquisition.
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Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study
TL;DR: The presence of NDM-1 β-lactamase-producing bacteria in environmental samples in New Delhi has important implications for people living in the city who are reliant on public water and sanitation facilities.
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Resistance Plasmid Families in Enterobacteriaceae
TL;DR: Bacteria carry extrachromosomal, self-replicating genetic elements called plasmids, which do not carry genes essential for the growth of host cells under nonstressed conditions.