Plasmodium falciparum clearance in clinical studies of artesunate-amodiaquine and comparator treatments in sub-Saharan Africa, 1999–2009
Citations
115 citations
Cites background from "Plasmodium falciparum clearance in ..."
...Second, as delayed clearance of parasites after therapy is uncommon and associated with high baseline parasitemia in Uganda, persistent parasitemia 2 days after the onset of therapy is likely not a reliable indicator of resistance [6,8]....
[...]
36 citations
Cites background from "Plasmodium falciparum clearance in ..."
...However, ACTs remain highly efficacious in subSaharan Africa (SSA) with fast clearance half-lives (Ashley et al., 2014; Zwang et al., 2014)....
[...]
23 citations
22 citations
17 citations
Cites background from "Plasmodium falciparum clearance in ..."
...falciparum resistance to artemisinin derivatives in Southeast Asia (where it was introduced for the first time in the mid-1990s), but so far it has not been detected in Africa (13)....
[...]
References
39 citations
"Plasmodium falciparum clearance in ..." refers background or methods in this paper
...We would like to thank Epicentre, Paris, France, for sharing the datasets [23,29-32,34-36] and all the principal investigators of the other studies....
[...]
...Details of the studies can be found elsewhere [26-40]....
[...]
36 citations
"Plasmodium falciparum clearance in ..." refers background in this paper
...Table 4 Clearance reduction, artesunate/amodiaquine groups Country site Parasitaemia, geometric mean N Parasite reduction ratio (individual data) d1/d0 d2/d0 d3/d0 d7/d0 Burkina faso - Nanoro 2008 21,185 295 97.8% 100.0% 100.0% 100.0% Cameroon 2006 24,129 110 97.0% 100.0% 100.0% 100.0% Gabon - Fougamou 2008 21,117 80 98.6% 100.0% 100.0% 100.0% Gabon 1999 20,867 108 98.2% 100.0% 100.0% 100.0% Kenya 1999 30,040 199 94.5% 99.9% 100.0% 100.0% Kenya 2009 12,193 54 99.2% 100.0% 100.0% 100.0% Madagascar 2006 9,648 119 98.9% 100.0% 100.0% 100.0% Mali Bougoula 2006 23,744 135 93.8% 99.9% 100.0% 100.0% Mozambique - Manhica 2008 35,924 210 77.1% 99.8% 100.0% 100.0% Nigeria - Afokang 2008 20,326 92 96.3% 99.7% 100.0% 100.0% Nigeria - Pamol 2008 17,329 82 97.9% 99.8% 100.0% 100.0% Senegal 1999 41,753 160 89.5% 99.8% 100.0% 100.0% Senegal 2006 20,201 264 91.4% 99.7% 100.0% 100.0% Uganda - Mbarara 2008 27,262 160 98.4% 100.0% 100.0% 100.0% Zambia - Ndola 2008 35,887 85 91.9% 100.0% 100.0% 100.0% Zanzibar Kivunge 2002 20,625 148 95.7% 100.0% 100.0% 100.0% Zanzibar Micheweni 2002 18,236 54 95.2% 99.7% 100.0% 100.0% Total 23,596 2355 93.9% 99.9% 100.0% 100.0%...
[...]
...5Department of Parasitology, Faculty of Medicine, Cheikh Anta Diop University, Dakar, Sénégal....
[...]
...8Institut de Recherche pour le Développement (IRD) Unité mixte de Recherche 198, Dakar BP 1386, Sénégal....
[...]
...Out of the 27 studies included (conducted between 1999 and 2009), three were multi-country studies [17-19], two studies compared ASAQ fixed and loose combination [20-22] and three studies were non-comparative (in Sierra Leone [23] and Senegal [24,25])....
[...]
36 citations
"Plasmodium falciparum clearance in ..." refers background in this paper
...However, as of today, in the clinic as well as in the field the parasite clearance time (PCT) and its related clinical phenotype (delayed PCT) remain the best practical surrogates of artemisinin in vivo resistance [8]; the problem is that the frequent sampling (every six or eight hours) required to measure PCT accurately and to estimate the parasite clearance half-life [9] is practically difficult even in research settings....
[...]
32 citations
20 citations
"Plasmodium falciparum clearance in ..." refers background or methods in this paper
...Out of the 27 studies included (conducted between 1999 and 2009), three were multi-country studies [17-19], two studies compared ASAQ fixed and loose combination [20-22] and three studies were non-comparative (in Sierra Leone [23] and Senegal [24,25])....
[...]
...We would like to thank Epicentre, Paris, France, for sharing the datasets [23,29-32,34-36] and all the principal investigators of the other studies....
[...]