Platelet Biogenesis in the Lung Circulation
TL;DR: It is concluded that the lung has significant hematopoietic potential including being a major site of platelet biogenesis and orthotopic, single-lung transplantation experiments into thrombocytopenic and hematOPoietIC progenitor-deficient animals revealed that peripheral blood platelet counts and bone marrow hematopolietic progenitors could be fully reconstituted by the lung transplant procedure.
About: This article is published in Blood.The article was published on 2018-11-21. It has received 29 citations till now. The article focuses on the topics: Thrombopoietin & Megakaryocyte.
Citations
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TL;DR: Single-cell RNA sequencing of human MKs from embryonic yolk sac and fetal liver is used to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis and identifies a subpopulation of CD42b+CD14+ MKs in vivo that exhibit high expression of genes associated with immune responses.
66 citations
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TL;DR: The presence of platelet aggregates and macrothrombocytes indicating increased platelet activity could be consistent with severe COVID-19 infection and is further evidence of the important role that platelets play when CO VID-19 manifests with thrombotic complications or respiratory failure.
Abstract: Thrombocytopenia is common in an intensive care unit (ICU) setting due to endogenous and iatrogenic factors. Despite that, thrombocytopenia in patients with severe COVID-19 infections is surprisingly uncommon. By examining the blood film of 20 ICU patients with COVID-19, we observed the presence of platelet aggregates and macrothrombocytes indicating increased platelet activity. We compared these findings with 20 blood films of non-severe COVID-19 cases where these findings were absent. These morphology features could be consistent with severe COVID-19 infection and is further evidence of the important role that platelets play when COVID-19 manifests with thrombotic complications or respiratory failure.
37 citations
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TL;DR: Findings support the notion that the lung plays an independent role in the development and functional maturation of MKs, and highlight the existence of a lung-specific MK phenotype that is skewed toward roles in immunity and inflammation.
33 citations
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TL;DR: Este es el reporte de situación COVID-19 Colombia No 130 - 27 de agosto de 2020.
Abstract: Este es el reporte de situación COVID-19 Colombia No 130 - 27 de agosto de 2020
24 citations
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TL;DR: The immune potential of platelets is dependent in part on their megakaryocyte precursor providing them with the molecular composition to be first responders and immune sentinels in initiating and orchestrating coordinated pathogen immune responses as discussed by the authors .
Abstract: Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has received significant research attention for >150 years. The immune cell functions of platelets are much less appreciated. Platelets interact with and activate cells of all branches of immunity in response to pathogen exposures and infection, as well as in response to sterile tissue injury. In this review, we focus on innate immune mechanisms of platelet activation, platelet interactions with innate immune cells, as well as the intersection of platelets and adaptive immunity. The immune potential of platelets is dependent in part on their megakaryocyte precursor providing them with the molecular composition to be first responders and immune sentinels in initiating and orchestrating coordinated pathogen immune responses. There is emerging evidence that extramedullary megakaryocytes may be immune differentiated compared with bone marrow megakaryocytes, but the physiological relevance of immunophenotypic differences are just beginning to be explored. These concepts are also discussed in this review. The immune functions of the megakaryocyte/platelet lineage have likely evolved to coordinate the need to repair a vascular breach with the simultaneous need to induce an immune response that may limit pathogen invasion once the blood is exposed to an external environment.
22 citations
References
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TL;DR: Single-cell RNA sequencing of human MKs from embryonic yolk sac and fetal liver is used to characterize the transcriptome, cellular heterogeneity, and developmental trajectories of early megakaryopoiesis and identifies a subpopulation of CD42b+CD14+ MKs in vivo that exhibit high expression of genes associated with immune responses.
66 citations
••
TL;DR: The presence of platelet aggregates and macrothrombocytes indicating increased platelet activity could be consistent with severe COVID-19 infection and is further evidence of the important role that platelets play when CO VID-19 manifests with thrombotic complications or respiratory failure.
Abstract: Thrombocytopenia is common in an intensive care unit (ICU) setting due to endogenous and iatrogenic factors. Despite that, thrombocytopenia in patients with severe COVID-19 infections is surprisingly uncommon. By examining the blood film of 20 ICU patients with COVID-19, we observed the presence of platelet aggregates and macrothrombocytes indicating increased platelet activity. We compared these findings with 20 blood films of non-severe COVID-19 cases where these findings were absent. These morphology features could be consistent with severe COVID-19 infection and is further evidence of the important role that platelets play when COVID-19 manifests with thrombotic complications or respiratory failure.
37 citations
••
TL;DR: Findings support the notion that the lung plays an independent role in the development and functional maturation of MKs, and highlight the existence of a lung-specific MK phenotype that is skewed toward roles in immunity and inflammation.
33 citations
••
TL;DR: Este es el reporte de situación COVID-19 Colombia No 130 - 27 de agosto de 2020.
Abstract: Este es el reporte de situación COVID-19 Colombia No 130 - 27 de agosto de 2020
24 citations