Podocyte as the Target for Aldosterone: Roles of Oxidative Stress and Sgk1
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...Tempol also prevented aldosterone-induced Sgk-1 expression in cultured podocytes ex vivo (Shibata et al., 2007)....
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Cites background or result from "Podocyte as the Target for Aldoster..."
...…effective in preventing or moderating hypertension in uninephrectomized rats given a high-salt diet and DOCA (Beswick et al., 2001; Adeagbo et al., 2003; Awe et al., 2003; Nakano et al., 2003; Ghosh et al., 2004) or aldosterone (Nishiyama et al., 2004a; Hirono et al., 2007; Shibata et al., 2007)....
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..., 2004) to 6 (Shibata et al., 2007) mmol/l or infused subcutaneously at 87 mol kg 1 day 1 (Adeagbo et al....
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...Blockade of mineralocorticosteroid receptors with eplerenone or the administration of tempol to uninephrectomized rats infused with aldosterone and fed an 8% NaCl diet blocked the development of hypertension, proteinuria, oxidative stress, podocyte damage, and up-regulation of the aldosterone effector kinase-1 in glomerular podocytes (Shibata et al., 2007)....
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...…2003; Ghosh et al., 2004; Iglarz et al., 2004) to 6 (Shibata et al., 2007) mmol/l or infused subcutaneously at 87 mol kg 1 day 1 (Adeagbo et al., 2003; Awe et al., 2003) produced a 29 (Nakano et al., 2003) to 106% (Shibata et al., 2007) normalization of BP, which averaged 73% among these studies....
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...…or the administration of tempol to uninephrectomized rats infused with aldosterone and fed an 8% NaCl diet blocked the development of hypertension, proteinuria, oxidative stress, podocyte damage, and up-regulation of the aldosterone effector kinase-1 in glomerular podocytes (Shibata et al., 2007)....
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