Poly(ADP-ribose) signaling in cell death
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"Poly(ADP-ribose) signaling in cell ..." refers background in this paper
...However, intracellular proteins are delivered by chaperone-mediated autophagy (CMA), microautophagy or macroautophagy (Dice, 2007; Klionsky et al., 2008; Kroemer et al., 2010; Levine and Kroemer, 2008)....
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...Through catabolism and recycling, the cells maintain the nutrient and energy homeostasis, and thus autophagy constitutes a major protective mechanism that allows cells to survive in response to multiple stresses and defend the organism against degenerative, infectious and neoplastic diseases (Levine and Kroemer, 2008)....
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...…recycling, the cells maintain the nutrient and energy homeostasis, and thus autophagy constitutes a major protective mechanism that allows cells to survive in response to multiple stresses and defend the organism against degenerative, infectious and neoplastic diseases (Levine and Kroemer, 2008)....
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5,831 citations
"Poly(ADP-ribose) signaling in cell ..." refers background in this paper
...Under normal conditions, long-lived cellular proteins are degraded by proteasome, but during periods of starvation or during ER stress long-lived, short-lived and misfolded proteins are recycled by the autophagic pathway to maintain ATP levels compatible with cell survival (Mizushima et al., 2008)....
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"Poly(ADP-ribose) signaling in cell ..." refers background in this paper
...AIF has long been known as a 57 kDa soluble protein confined to the mitochondrial intermembrane space (Susin et al., 1999)....
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3,647 citations
"Poly(ADP-ribose) signaling in cell ..." refers background in this paper
...AMPK is a positive regulator and mTOR is a negative regulator of autophagy, because during nutrient deprivation AMPK is able to inhibit mTORC1 through phosphorylation of TSC2 and raptor (Inoki et al., 2003; Schenck et al., 2008)....
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