Journal ArticleDOI
Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux.
Rupa D. Dabholkar,Rishikesh M. Sawant,Dimitriy A. Mongayt,Padma V. Devarajan,Vladimir P. Torchilin +4 more
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TLDR
PCL-containing PEG(2000)-PE/TPGS micelles were stable in vitro under various conditions modeling the physiological ones, in particular, at low pH values and in the presence of bile acids, which is especially important for their possible oral administration.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2006-06-06. It has received 192 citations till now. The article focuses on the topics: Micelle & Polyethylene glycol.read more
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Vitamin E TPGS as a molecular biomaterial for drug delivery
TL;DR: TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles.
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Polymeric micelles drug delivery system in oncology
TL;DR: Seven PM formulations of anti-tumor drugs being evaluated in clinical trials are reviewed in this paper, in terms of formulation study, in vitro cytotoxicity, in vivo pharmacokinetics, anti-Tumor efficacy and safety as well as clinical trials, to shed new light on the discovery of novel PM formulations.
Journal ArticleDOI
Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs.
Ying Lu,Kinam Park,Kinam Park +2 more
TL;DR: The potential of polymeric micelles for delivery of poorly water-soluble drugs, especially in the areas of oral delivery and in cancer therapy, is discussed and other possible strategies related to particle size reduction for enhancing solubilization of poorlyWater-Soluble drugs are introduced.
Journal ArticleDOI
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals.
TL;DR: The present work concisely reviews different administration routes as well as the advantages and disadvantages of each method, highlighting why oral delivery is currently the most promising approach.
Journal ArticleDOI
Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs
Wei Xu,Peixue Ling,Tianmin Zhang +2 more
TL;DR: The primary purpose of this paper is to illustrate the potential of PMs for delivery of poorly water-soluble drugs with bioavailability being well maintained.
References
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Journal ArticleDOI
Hypersensitivity reactions from taxol.
Raymond B. Weiss,Ross C. Donehower,Peter H. Wiernik,T Ohnuma,R J Gralla,Donald L. Trump,J R Baker,D. A. Van Echo,D. D. Von Hoff,Brian Leyland-Jones +9 more
TL;DR: Hypersensitivity reactions to taxol have been one of the toxicities observed with administration of this drug and guidelines are provided to prevent or minimize such toxicity and treat reactions if they still occur.
Journal ArticleDOI
Paclitaxel and its formulations.
TL;DR: There is a need for the development of alternate formulation of paclitaxel having good aqueous solubility and at the same time free of any side effects.
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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
A. Sparreboom,J. van Asperen,U. Mayer,A.H. Schinkel,Johan W. Smit,Dkf Meijer,Piet Borst,W. J. Nooijen,Jos H. Beijnen,O. van Tellingen +9 more
TL;DR: It is concluded that P-glycoprotein limits the oral uptake of paclitaxel and mediates direct excretion of the drug from the systemic circulation into the intestinal lumen.
Journal ArticleDOI
Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs
TL;DR: This review article focuses on micelles prepared from conjugates of water-soluble polymers, such as polyethylene glycol or polyvinyl pyrrolidone (PVP), with phospholipids or long-chain fatty acids, and considers the preparation of targeted immunomicelles with specific antibodies attached to their surface.
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Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers.
TL;DR: The results suggest that surfactants can inhibit multiple transporters but that changes in membrane fluidity may not be a generalized mechanism to reduce transporter activity.