Polyisoprenylated benzophenones from Garcinia pedunculata
TL;DR: Pedunculol, a polyisoprenylated benzophenone derivative, together with garcinol and cambogin has been isolated from the pericarp of Garcinia pedunculata as mentioned in this paper.
About: This article is published in Phytochemistry.The article was published on 1989-01-01. It has received 42 citations till now. The article focuses on the topics: Garcinia pedunculata & Derivative (chemistry).
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TL;DR: In a phenazine methosulfate/NADH-nitroblue tetrazolium system, garcinol exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum albumin/fructose system, suggesting it might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions.
Abstract: Garcinol, a polyisoprenylated benzophenone derivative, was purified from Garcinia indica fruit rind, and its antioxidative activity, chelating activity, free radical scavenging activity, and anti-glycation activity were studied. Garcinol exhibited moderate antioxidative activity in the micellar linoleic acid peroxidation system and also exhibited chelating activity at almost the same level as citrate. It also showed nearly 3 times greater DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging activity than DL-alpha-tocopherol by weight in aqueous ethanol solution. In a phenazine methosulfate/NADH-nitroblue tetrazolium system, garcinol exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum albumin/fructose system. Thus, garcinol might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions.
480 citations
419 citations
TL;DR: This work will review natural benzophenones and provide an in-depth discussion of their structural diversity and biological activity, and select examples mostly from the last 15 years, but extending the scope to other historically important benzophenone discovered prior to that time.
156 citations
TL;DR: Garcinia is a large genus of polygamous trees or shrubs, distributed in the tropical Asia, Africa and Polynesia and is a rich source of bioactive molecules including xanthones, flavonoids, benzophenones, lactones and phenolic acids as discussed by the authors.
95 citations
TL;DR: This study is the first report on the in vitro antibacterial activity of extracts from the fruit rinds of G. cowa and G. pedunculata and it was found that the hexane and chloroform extracts exhibited marked inhibitory effect against all the test organisms and were more effective than that of the other extracts.
Abstract: The crude hexane and chloroform extracts from the fruit rinds of Garcinia cowa and Garcinia pedunculata were studied for their antibacterial activity against some foodborne pathogens and spoilage bacteria such as Bacillus cereus , Bacillus coagulans , Bacillus subtilis , Staphylococcus aureus and Escherichia coli . The minimum inhibitory concentrations (MICs) of the extracts determined by the agar dilution method were ranging from 15 to 500 μg/ml and 300 to 1250 μg/ml for G. cowa and G. pedunculata , respectively. However, the hexane and chloroform extracts from the fruit rinds of G. cowa exhibited marked inhibitory effect against all the test organisms and were more effective than that of G. pedunculata extracts. The antibacterial activity of all the extracts was more pronounced against the tested Gram-positive bacteria than the tested Gram-negative bacterium. Furthermore, this study is the first report on the in vitro antibacterial activity of extracts from the fruit rinds of G. cowa and G. pedunculata .
82 citations
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TL;DR: A new polyisoprenylated phenolic pigment, garcinol, and its colourless isogarcinol, have been isolated from Garcinia indica and their structures proposed on the basis of chemical and spectral data.
102 citations
TL;DR: Two isoprenylated benzophenone derivatives of Garcinia cambogia have been isolated from the latex of the plant and the structure of the derivatives has been deduced.
77 citations