Journal ArticleDOI
Polymeric worm micelles as nano-carriers for drug delivery.
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TLDR
W worm micelles as blends of degradable polylactic acid and inert block copolymer amphiphiles were prepared for controlled release and initial study of carrier transport through nano-porous media, suggesting a new class of hydrophobic drug nano-carriers that are capable of tissue permeation as well as controlled release.Abstract:
Nanoscale carriers of active compounds, especially drugs, need not be spherical in shape. Worm micelles as blends of degradable polylactic acid (PLA) and inert block copolymer amphiphiles were prepared for controlled release and initial study of carrier transport through nano-porous media. The loading capacity of a typical hydrophobic drug, Triamterene, and the release of hydrophobic dyes were evaluated together with morphological changes of the micelles. Degradation of PLA by hydrolysis led to the self-shortening of worms and a clear transition towards spherical micelles, correlating with the release of hydrophobic dyes. Perhaps equally important for application is the flexibility of worm micelles, which we show allows them to penetrate nanoporous gels where 100 nm sized vesicles cannot enter. Such gels have served as tissue models, and so the results here collectively suggest a new class of hydrophobic drug nano-carriers that are capable of tissue permeation as well as controlled release.read more
Citations
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Beyond the sparkle: the impact of nanodiamonds as biolabeling and therapeutic agents.
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Polymeric filomicelles and nanoworms: two decades of synthesis and application
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Pointed-oval-shaped micelles from crystalline-coil block copolymers by crystallization-driven living self-assembly.
TL;DR: By using this crystallization-driven living self-assembly approach, the formation of unusual nanoscopic architectures such as pointed ovals and hierarchical pointed-oval-based co-micelle architectures is also possible.
Journal ArticleDOI
Ionic Liquids: Versatile Media for Preparation of Vesicles from Polymerization-Induced Self-Assembly
Qi Zhang,Shiping Zhu +1 more
TL;DR: In this paper, a new polymerization-induced self-assembly (PISA) system through reversible addition-fragmentation chain transfer (RAFT)-mediated dispersion polymerization in ionic liquids was developed.
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Degradable Poly(β-amino ester) nanoparticles for cancer cytoplasmic drug delivery
TL;DR: The BAE-PEG nanoparticles were shown to rapidly enter cancer cells, localize in their endosomes/lysosomes, and subsequently disrupt them to release the drugs into the cytosol.
References
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Journal ArticleDOI
Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
Journal ArticleDOI
Polymeric micelles - a new generation of colloidal drug carriers.
TL;DR: This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery and potential medical applications, especially in cancer chemotherapy, are described and discussed.
Journal ArticleDOI
On the Origins of Morphological Complexity in Block Copolymer Surfactants
Sumeet Jain,Frank S. Bates +1 more
TL;DR: Experiments with poly(1,2-butadiene-b-ethylene oxide) diblock copolymers are described, which form Y-junctions and three-dimensional networks in water at weight fractions of PEO intermediate to those associated with vesicle and wormlike micelle morphologies.
Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
TL;DR: With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.
Journal ArticleDOI
Giant Wormlike Rubber Micelles
TL;DR: A low molecular weight poly(ethyleneoxide)-poly(butadiene) (PEO-PB) diblock copolymer containing 50 weight percent PEO forms gigantic wormlike micelles at low concentrations (<5 percent by weight) in water.
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