Journal ArticleDOI
Polymersome Nanoreactor-Mediated Combination Chemodynamic-Immunotherapy via ROS Production and Enhanced STING Activation
Qinghao Zhou,Yuheng Wang,Xiang Li,Nannan Lu,Zhishen Ge +4 more
- Vol. 4, Iss: 11, pp 2100130
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TLDR
Ferrocene-containing polymersome nanoreactors are engineered by co-loading glucose oxidase and STING agonist, symmetry-linked amidobenzimidazole (DiABZI) and CDT synergistically enhance the antitumor immunity via combination chemodynamic-immunotherapy.Abstract:
Stimulator of interferon genes (STING) activation by STING agonists has been recognized as one of important immunotherapy strategies. However, immunosuppressive tumor microenvironment always hinders the therapeutic efficacy of cancer immunotherapy. Herein, ferrocene-containing polymersome nanoreactors are engineered by co-loading glucose oxidase (GOD) and STING agonist, symmetry-linked amidobenzimidazole (DiABZI), for enhanced STING activation and combination chemodynamic-immunotherapy. After intravenous injection, the polymersomes can accumulate in tumor tissues. The tumor acidity-triggered polymersome membrane permeability allows the entrance of tumoral glucose and oxygen for H2O2 production by GOD, which is further transformed into hydroxyl radicals (•OH) under the catalysis of ferrocene moieties. Chemodynamic therapy (CDT) based on •OH can induce efficient cellular apoptosis and release of fragmented DNA and tumor-associated antigens to promote endogenous STING activation and reverse immunosuppressive tumor microenvironment. Simultaneously, pH-responsive release of DiABZI activates STING pathway to elicit antitumor immune responses. Therefore, DiABZI and CDT synergistically enhance the antitumor immunity via combination chemodynamic-immunotherapy. The primary tumors are completely ablated and the growth of distant tumors that are established after treatment is also suppressed efficiently. The polymersome nanoreactor-mediated chemodynamic-immunotherapy represents a promising treatment strategy toward primary solid and metastatic tumors.read more
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Journal ArticleDOI
Engineered nanomaterials for synergistic photo-immunotherapy.
TL;DR: Wang et al. as discussed by the authors investigated the latest strategies on engineering nanomaterials to enhance the anti-cancer efficiency of synergistic photo-immunotherapy, with emphasis on the activation of anti-tumor immune response, the reversal of tumor immunosuppressive microenvironment (TIME), the regulation of the interaction between immunosensressive cells and tumor cells, the infiltration of immune cells and improved efficiency of photo-IMmunotherapy-induced ICD.
Understanding the tumor immune microenvironment (TIME) for effective therapy
Mikhail Binnewies,Edward W. Roberts,Kelly Kersten,Vincent Chan,Douglas F. Fearon,Miriam Merad,Lisa M. Coussens,Dmitry I. Gabrilovich,Suzanne Ostrand-Rosenberg,Suzanne Ostrand-Rosenberg,Catherine C. Hedrick,Robert H. Vonderheide,Mikael J. Pittet,Rakesh K. Jain,Weiping Zou,T. Kevin Howcroft,Elisa C. Woodhouse,Robert A. Weinberg,Matthew F. Krummel +18 more
TL;DR: In this article, the authors parse the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient's tumor, and reveal new therapeutic targets to predict and guide immunotherapeutic responsiveness.
Journal ArticleDOI
Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy
TL;DR: This review provides an update on the recent advances in Fe-based nanoplatforms for combined PTT/CDT for multifunctional theranostics and highlights the important scientific obstacles that require resolution in order to reach greater heights of clinical success.
Journal ArticleDOI
Redox- and pH-Responsive Polymersomes with Ferrocene Moieties Exhibiting Peroxidase-like, Chemoenzymatic Activity and H2O2-Responsive Release Behavior.
Silvia Moreno,Hanna Hübner,Christiane Effenberg,Susanne Boye,Anthony R. Ramuglia,Deborah Schmitt,Brigitte Voit,Inez M. Weidinger,Markus Gallei,Dietmar Appelhans +9 more
TL;DR: P pH-responsive and ferrocene-containing block copolymers were synthesized to realize pH-stable and multiresponsive polymersomes and tunable membrane properties for potential application in therapeutics are presented.
Journal ArticleDOI
Reactive oxygen species-powered cancer immunotherapy: Current status and challenges.
Mengying He,Mengyuan Wang,Tao Xu,Mengyao Zhang,Huaxing Dai,Chao Wang,Dawei Ding,Zhiyuan Zhong +7 more
TL;DR: In this paper , the authors introduce the concept of reactive oxygen species (ROS) powered cancer immunotherapy and highlight the innovative strategies to boost ROS-based cancer Immunotherapy, and discuss the challenges in terms of clinical translation.
References
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Journal ArticleDOI
Oncology Meets Immunology: The Cancer-Immunity Cycle
TL;DR: Emerging clinical data suggest that cancer immunotherapy is likely to become a key part of the clinical management of cancer and may be more effective in combination with agents that target other steps of the cycle.
Journal ArticleDOI
Cancer immunotherapy using checkpoint blockade
TL;DR: New-generation combinatorial therapies may overcome resistance mechanisms to immune checkpoint therapy, and evidence points to alterations that converge on the antigen presentation and interferon-γ signaling pathways.
Journal ArticleDOI
Neoantigens in cancer immunotherapy
TL;DR: Observations indicate that neoantigen load may form a biomarker in cancer immunotherapy and provide an incentive for the development of novel therapeutic approaches that selectively enhance T cell reactivity against this class of antigens.
Journal ArticleDOI
The future of immune checkpoint therapy
Padmanee Sharma,James P. Allison +1 more
TL;DR: The way forward for this class of novel agents lies in the ability to understand human immune responses in the tumor microenvironment, which will provide valuable information regarding the dynamic nature of the immune response and regulation of additional pathways that will need to be targeted through combination therapies to provide survival benefit for greater numbers of patients.
Journal ArticleDOI
Cancer immunotherapy comes of age
TL;DR: In the context of advances in the understanding of how tolerance, immunity and immunosuppression regulate antitumour immune responses, these successes suggest that active immunotherapy represents a path to obtain a durable and long-lasting response in cancer patients.