Book ChapterDOI
Polyphenols as an Effective Therapeutic Intervention Against Cognitive Decline During Normal and Pathological Brain Aging.
S. Asha Devi,Anudita Chamoli +1 more
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TLDR
A combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.Abstract:
Research in animals and humans has indicated that polyphenols can delay the age-related decline in learning, memory and neurodegenerative diseases. Among the polyphenols, berry phenolics have extensive beneficial effects because of their antioxidant and anti-inflammatory properties. Long-term consumption of grapes results in accumulation of polyphenols in the brain, which modulates cell-signalling pathways and neutralises the redox imbalance in the aging brain. Here we review the in vivo and in vitro evidence for considering grape-derived polyphenolics, the flavonoids- catechins, epicatechin, anthocyanidin, and quercetin, and non-flavonoids-gallic acid and resveratrol, as effective dietary sources to facilitate cognition in adults and lessen the decline in the old and pathogenic states, Alzheimer's and Parkinson's disease. Furthermore, a combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.read more
Citations
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TL;DR: In this paper, the effects of these phytochemicals (either pure forms or polyphenolic-food) are reviewed and summarized according to affected cellular signaling pathways, and the effectiveness of the anti-aging preventive action of nutritional interventions based on diets rich in poly-phenolic food, such as the diets of the Blue zones, are discussed.
References
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Journal ArticleDOI
Fate of Microbial Metabolites of Dietary Polyphenols in Rats: Is the Brain Their Target Destination?
Mattia Gasperotti,Sabina Passamonti,Federica Tramer,Domenico Masuero,Graziano Guella,Fulvio Mattivi,Urska Vrhovsek +6 more
TL;DR: The brain was found to be a specific target organ for 10 of the 23 polyphenol metabolites injected, which significantly increased in the treated animals, providing new perspectives for understanding the role of diet on brain chemistry.
Journal ArticleDOI
Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats
Catarina Rendeiro,David Vauzour,Rebecca Kean,Laurie T. Butler,Marcus Rattray,Jeremy P. E. Spencer,Claire M. Williams +6 more
TL;DR: The present study suggests that consumption of flavonoid-rich blueberries has a positive impact on spatial learning performance in young healthy animals, and these improvements are linked to the activation of ERK–CREB–BDNF pathway in the hippocampus.
Journal ArticleDOI
Modulatory role of grape seed extract on age-related oxidative DNA damage in central nervous system of rats.
TL;DR: It is revealed that grape seed extract has inhibiting effect on the accumulation of age-related oxidative DNA damages in spinal cord and in various brain regions such as cerebral cortex, striatum and hippocampus.
Journal Article
Grape seed proanthocyanidin extract (GSPE) and antioxidant defense in the brain of adult rats.
TL;DR: Changes in the cholinergic system, however, indicate an increase in the ACh concentration with a moderate reduction in AChE activity, suggesting that PA may have a potent role in enhancing cognition in older rats.
Journal ArticleDOI
Bioavailability of dietary (poly)phenols: a study with ileostomists to discriminate between absorption in small and large intestine
TL;DR: Ileal fluid analysis revealed that even when absorption occurred in the small intestine, in subjects with a functioning colon a substantial proportion of the ingested components still pass from the small into the large intestine, where they may be either absorbed before or after catabolism by colonic bacteria.