Population-based sero-epidemiological study protocol for the impact of smoking on sars-cov-2 infection and covid-19 outcomes - the troina study
Riccardo Polosa,Valerio Tomaselli,Pietro Ferrara,A. C. Romeo,Sonja Rust,Daniela Saitta,Filippo Caraci,Carmelo Romano,M. Thangaraju,Pietro Zuccarello,Juliana Lundgren Rose,Margherita Ferrante,Jonathan Belsey,Fabio Cibella,Fabio Cibella,E. Interlandi,Raffaele Ferri +16 more
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TLDR
In this paper, the authors quantified the proportion of SARS-CoV-S antibody seroprevalence, studied the changes in antibody levels over time, and analyzed the association between smoking status and infection using serop-revence data.Abstract:
After the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), research has highlighted several aspects of the pandemic, focusing on clinical features and risk factors associated with infection and disease severity. However, emerging results on the role of smoking in SARS-CoV-2 infection susceptibility or COVID-19 outcomes are conflicting, and their robustness remains uncertain. In this context, this project aims at quantifying the proportion of SARS-CoV-S antibody seroprevalence, studying the changes in antibody levels over time, and analyzing the association between smoking status and infection using seroprevalence data. The added value of this research is that the current smoking status of the population to be studied will be biochemically verified, in order to avoid the bias associated with self-reported smoking status. As such, the results from this survey may provide actionable metric to study the role of smoking in SARS-CoV-2 spread, and therefore implement the most appropriate public health measures to control the pandemic. The research design involves a 6-month prospective cohort study with serial sampling of the same individuals. Each participant will be surveyed about their demographics and COVID-19-related information, and blood sampling will be collected upon recruitment and at specified follow-up time points (namely, after 8 and 24 weeks). Blood samples will be screened for the presence of SARS-CoV-2 specific antibodies and serum cotinine. Overall, we expect to find a higher prevalence of antibodies in individuals at high-risk for viral exposure (i.e., healthcare or other essential workers), according to previous literature, and to refine current estimates on the association between smoking status and SARS-CoV-2/COVID-19. Our results may serve as a reference for future clinical research and the methodology could be exploited in public health sectors and policies.read more
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
SARS-CoV-2 Seroprevalence Structure of the Russian Population during the COVID-19 Pandemic.
Anna Y. Popova,Viacheslav S. Smirnov,Elena E. Andreeva,Elena A. Babura,S. V. Balakhonov,Natalia S. Bashketova,Svetlana A. Bugorkova,Maxim V. Bulanov,Natalia. N. Valeullina,Viacheslav. V. Vetrov,Dmitriy. V. Goryaev,Tatyana N. Detkovskaya,Elena B. Ezhlova,Natalia N. Zaitseva,Olga A. Istorik,Irina V. Kovalchuk,Dmitriy N. Kozlovskikh,Svetlana Y. Kombarova,O. P. Kurganova,Alexander. E. Lomovtsev,Lena A. Lukicheva,Ludmila V. Lyalina,A. A. Melnikova,O. M. Mikailova,Alexei K. Noskov,Ludmila N. Noskova,Elena E. Oglezneva,Tatyana P. Osmolovskaya,Marina A. Patyashina,Natalia A. Penkovskaya,Lada V. Samoilova,Tatyana F. Stepanova,O. E. Trotsenko,Areg A. Totolian +33 more
TL;DR: In this paper, the authors investigated the distribution and cumulative proportions of individuals with antibodies (Abs) to the SARS-CoV-2 nucleocapsid antigen (Ag), in the period from June to December 2020, using a three-phase monitoring process.
References
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Journal ArticleDOI
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
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Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
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Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis.
Wei Jie Guan,Wenhua Liang,Yi Zhao,Heng Rui Liang,Zi Sheng Chen,Yimin Li,Xiaoqing Liu,Ru Chong Chen,Chun Li Tang,Tao Wang,Chun-Quan Ou,Li Li,Ping Yan Chen,Ling Sang,Wei Wang,Jianfu Li,Caichen Li,Li Min Ou,Bo Cheng,Shan Xiong,Zheng Yi Ni,Jie Xiang,Yu Hu,Lei Liu,Hong Shan,Chun Liang Lei,Yi Xiang Peng,Li Wei,Yong Liu,Ya Hua Hu,Peng Peng,Jian-ming Wang,Ji Yang Liu,Zhong Chen,Gang Li,Zhi Jian Zheng,Shao Qin Qiu,Jie Luo,Chang Jiang Ye,Shao Yong Zhu,Lin Ling Cheng,Feng Ye,Shi Yue Li,Jin Ping Zheng,Nuo Fu Zhang,Nanshan Zhong,Jianxing He +46 more
TL;DR: It is found that among laboratory confirmed cases of COVID-19, patients with any comorbidity yielded poorer clinical outcomes than those without and a greater number ofComorbidities also correlated with poorer clinical outcome.
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Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections.
Quanxin Long,Xiaojun Tang,Qiu Lin Shi,Qin Li,Hai Jun Deng,Jun Yuan,Jie Li Hu,Wei Xu,Yong Zhang,Fa Jin Lv,Kun Su,Fan Zhang,Jiang Gong,Bo Wu,Xia Mao Liu,Jin Jing Li,Jing Fu Qiu,Juan Chen,Ailong Huang +18 more
TL;DR: A cohort of asymptomatic patients infected with SARS-CoV-2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients.
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Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 — United States, February 12–March 28, 2020
TL;DR: Preliminary findings suggest that in the United States, persons with underlying health conditions or other recognized risk factors for severe outcomes from respiratory infections appear to be at a higher risk for severe disease from COVID-19 than are persons without these conditions.