Journal ArticleDOI
Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents
Jonathan F. Lovell,Cheng S. Jin,Cheng S. Jin,Elizabeth Huynh,Elizabeth Huynh,Honglin Jin,Honglin Jin,Chulhong Kim,John L. Rubinstein,Warren C. W. Chan,Weiguo Cao,Lihong V. Wang,Gang Zheng,Gang Zheng +13 more
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TLDR
The development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.Abstract:
Optically active nanomaterials promise to advance a range of biophotonic techniques through nanoscale optical effects and integration of multiple imaging and therapeutic modalities. Here, we report the development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties. Porphysomes enabled the sensitive visualization of lymphatic systems using photoacoustic tomography. Near-infrared fluorescence generation could be restored on dissociation, creating opportunities for low-background fluorescence imaging. As a result of their organic nature, porphysomes were enzymatically biodegradable and induced minimal acute toxicity in mice with intravenous doses of 1,000 mg kg^(−1). In a similar manner to liposomes, the large aqueous core of porphysomes could be passively or actively loaded. Following systemic administration, porphysomes accumulated in tumours of xenograft-bearing mice and laser irradiation induced photothermal tumour ablation. The optical properties and biocompatibility of porphysomes demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy.read more
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Nanoparticles in photodynamic therapy.
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Dopamine‐Melanin Colloidal Nanospheres: An Efficient Near‐Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy
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Nanoparticles for photothermal therapies.
Daniel Jaque,L. Martínez Maestro,B. del Rosal,Patricia Haro-González,Antonio Benayas,Antonio Benayas,José Luis Plaza,E. Martín Rodríguez,J. García Solé +8 more
TL;DR: The current status of the use of nanoparticles for photothermal treatments is reviewed in detail, paying special attention to the physical mechanisms at the root of the light-to-heat conversion processes.
References
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Toxic Potential of Materials at the Nanolevel
TL;DR: The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
Journal ArticleDOI
Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
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Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
TL;DR: It is found that, after exposure to continuous red laser at 800 nm, malignant cells require about half the laser energy to be photothermally destroyed than the nonmalignant cells, so both efficient cancer cell diagnostics and selective photothermal therapy are realized at the same time.
Journal ArticleDOI
Photodynamic therapy for cancer
TL;DR: PDT is being tested in the clinic for use in oncology — to treat cancers of the head and neck, brain, lung, pancreas, intraperitoneal cavity, breast, prostate and skin.