Positioning metal-organic framework nanoparticles within the context of drug delivery - A comparison with mesoporous silica nanoparticles and dendrimers.
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...[16,41,42] To successfully achieve nanoparticle-based drug del ivery that could reach pharmaceuticals market, the critical considerations of a biodegradable and nontoxic nano c rrier, made of nontoxic components that are easil y cleared from the body after NP decomposition, must still be taken into account.[43,44] Last but not least, the NP-based...
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...[49] Therefore, the pore size and shape of MOFs is defined by the geometry of both the inorgan ic clusters and the organic linkers as well as by t heir connectivity.[50] The large diversity of inorganic and organic components has allowed for the synthesi s of an abundant number of different MOFs....
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...[75] This systematic approach, consisting in varying the organic linker l ngth of MOF structure without changing its underl ying topology, is called isoreticular expansion (Figure 3).[50] The challenge of the implementation of this chemical approach to build MOF NPs relies on the demanding s ynthesis of extended organic linkers together with solubility issues, making MOF NPs syntheses expensive and thus decreasing their industrial applicability and econ omic feasibility....
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