Positioning single atoms with a scanning tunnelling microscope
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Cites background from "Positioning single atoms with a sca..."
...These are (1) strand invasion, (2) an excess of staples, (3) cooperative effects and (4) design that intentionally does not rely on binding between staples....
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...But the widespread use of scaffolded self-assembly, and in particular the use of long DNA scaffolds in combination with hundreds of short strands, has been inhibited by several misconceptions: it was assumed that (1) sequencesmust be optimized(20) to avoid secondary structure or undesired binding interactions, (2) strands must be highly purified, and (3) strand concentrations must be precisely equimolar....
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Cites background from "Positioning single atoms with a sca..."
...The decades since then have seen the invention of the scanning tunnelling microscope that allows us to image and manipulate individual molecules and atom...
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References
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