Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells
Citations
483 citations
Cites background from "Positive regulation of migration an..."
...Up-regulated proteins include filamins (FLNA and FLNB), actin cross-linkers that anchor membrane proteins to the actin cytoskeleton (33); F11 receptor, an important regulator of tight junction assemblies (34); plectin-1, a cross-linker of actin, microtubules, and intermediate filaments (35); VASP (vasodilator-stimulated phosphoprotein), involved in invasive migration of cancer cells (36); S100A4, a metastasis promoter involved in up-regulation of matrix metalloproteases (MMPs) and down-regulation of tissue inhibitors of matrix metalloprotease (TIMPs) (37); VCL (vinculin), involved in anchoring F-actin to the membrane (38); and LGALS3 (lectin, galactoside-binding, soluble-3), a protein that cross-links Mgat-5 to the cell surface....
[...]
238 citations
192 citations
160 citations
100 citations
Cites background from "Positive regulation of migration an..."
...VASP was involved in migfilin-mediated cell-matrix adhesions and migration; however, VASP exerted its positive modulation of migration and invasion via Rac1 in human breast cancer cells [21-23]....
[...]
References
10,451 citations
"Positive regulation of migration an..." refers background in this paper
...It has been found that 21 short nucleotide (nt) ds RNA molecules, known as short interfering RNAs (siRNAs), can mediate RNAi in mammalian cell lines (19)....
[...]
6,076 citations
"Positive regulation of migration an..." refers background in this paper
...As a significant member of the Rho family, Rac1 has been implicated in tumorigenesis (2), tumor angiogenesis (3), invasion and metastasis (4), cell-cycle control and apoptosis (5)....
[...]
2,520 citations
Additional excerpts
...progression and cell-cell adhesion (1)....
[...]
959 citations
"Positive regulation of migration an..." refers background in this paper
...Furthermore, the addition of VASP resulted in an increase in bacterial speed in the in vitro reconstitution assays of Listeria motility (34)....
[...]
...That VASP can affect the cell movements of bacteria, mouse melanoma cells, human platelet, fibroblasts and neurons by regulating cytoskeleton has been detected (14,15,34,35)....
[...]
939 citations
"Positive regulation of migration an..." refers background in this paper
...During cell migration, activated Rac and Cdc42 induce reorganization of the actin cytoskeleton at the leading edge (6)....
[...]