Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells
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...Up-regulated proteins include filamins (FLNA and FLNB), actin cross-linkers that anchor membrane proteins to the actin cytoskeleton (33); F11 receptor, an important regulator of tight junction assemblies (34); plectin-1, a cross-linker of actin, microtubules, and intermediate filaments (35); VASP (vasodilator-stimulated phosphoprotein), involved in invasive migration of cancer cells (36); S100A4, a metastasis promoter involved in up-regulation of matrix metalloproteases (MMPs) and down-regulation of tissue inhibitors of matrix metalloprotease (TIMPs) (37); VCL (vinculin), involved in anchoring F-actin to the membrane (38); and LGALS3 (lectin, galactoside-binding, soluble-3), a protein that cross-links Mgat-5 to the cell surface....
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Cites background from "Positive regulation of migration an..."
...VASP was involved in migfilin-mediated cell-matrix adhesions and migration; however, VASP exerted its positive modulation of migration and invasion via Rac1 in human breast cancer cells [21-23]....
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References
467 citations
"Positive regulation of migration an..." refers background in this paper
...This is particularly attractive since PKG colocalizes with VASP in dynamic membrane regions, and the latter is a wellcharacterized substrate for PKG (30)....
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...Fryer and Field (16) indicated that there was overlap in the phenotypic regulation by PKG, Rac and Pak especially in endothelial permeability, focal adhesion remodeling, and angiogenesis....
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...PKG may facilitate the complex formation between Rac1 and an exchange factor by modification of a scaffolding protein such as members of the ENA/VASP family of proteins....
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...In agreement with previous studies, the study by Fryer et al on endothelial cells proved that PKG controls cell morphology through Pak by regulation of the Pak/VASP association while Pak is a substrate of Rac (29)....
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...PKG and its substrate VASP appear to regulate Rac/Pak activity....
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462 citations
"Positive regulation of migration an..." refers background in this paper
...In some cell types Rac1 up-regulation was shown to result in the inhibition of migration such as Rac1 overexpression in Madin-Darby canine kidney (MDCK) epithelial cells which resulted in the inhibition of migration and invasion (7)....
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435 citations
"Positive regulation of migration an..." refers background in this paper
...The deletion of the Ena/VASP-binding sites within the bacterial protein ActA led to a decrease in the actindependent intracellular motility of Listeria monocytogenes (14)....
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...Deletion of the Ena/VASP-binding sites within the bacterial protein ActA led to a decrease in the actin-dependent intracellular motility of Listeria monocytogenes (14)....
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...That VASP can affect the cell movements of bacteria, mouse melanoma cells, human platelet, fibroblasts and neurons by regulating cytoskeleton has been detected (14,15,34,35)....
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278 citations
"Positive regulation of migration an..." refers background in this paper
...There is increasing evidence that Rho proteins influence a variety of important processes in cancer, including cell transformation, survival, proliferation, invasion, metastasis and angiogenesis (25)....
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219 citations
"Positive regulation of migration an..." refers background in this paper
...Migration was shown to be unchanged in Rac1-deficient colon carcinoma cells (8), rat fibroblasts (9) and macrophages (10)....
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