Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells
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...Up-regulated proteins include filamins (FLNA and FLNB), actin cross-linkers that anchor membrane proteins to the actin cytoskeleton (33); F11 receptor, an important regulator of tight junction assemblies (34); plectin-1, a cross-linker of actin, microtubules, and intermediate filaments (35); VASP (vasodilator-stimulated phosphoprotein), involved in invasive migration of cancer cells (36); S100A4, a metastasis promoter involved in up-regulation of matrix metalloproteases (MMPs) and down-regulation of tissue inhibitors of matrix metalloprotease (TIMPs) (37); VCL (vinculin), involved in anchoring F-actin to the membrane (38); and LGALS3 (lectin, galactoside-binding, soluble-3), a protein that cross-links Mgat-5 to the cell surface....
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...VASP was involved in migfilin-mediated cell-matrix adhesions and migration; however, VASP exerted its positive modulation of migration and invasion via Rac1 in human breast cancer cells [21-23]....
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References
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"Positive regulation of migration an..." refers background in this paper
...Pan has successfully suppressed the Rac1 expression by using Rac1-specific siRNA and demonstrated that the conditioned medium from these Rac1 siRNA-targeted cancer cells can effectively inhibit endothelial cell proliferation (12)....
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...The expression of a dominant-negative form of Rac in elongated cells, such as B16F10 melanoma cells, inhibits the formation of such protrusive membrane structures, causing decreased cell migration (12)....
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"Positive regulation of migration an..." refers background in this paper
...Cdc42-binding effector, to regulate actin assembly and membrane protrusion at the cellular leading edge (28)....
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122 citations
"Positive regulation of migration an..." refers background in this paper
...A number of apparently conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in the promotion and inhibition of actindependent processes (13)....
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"Positive regulation of migration an..." refers background in this paper
...Activated Rac1 localizes to the plasma membrane where it is thought to function in actin remodeling which contributes to membrane ruffling (26,27)....
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