Journal ArticleDOI
Possible role for avPGC-1α in the control of expression of fiber type, along with avUCP and avANT mRNAs in the skeletal muscles of cold-exposed chickens
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TLDR
An increase in the number of fast‐oxidative‐glycolytic (type IIA) fibers in the pectoralis muscle, which contains exclusively type IIB fibers in control chickens, was observed in cold‐acclimated chickens, providing novel information about possible regulatory pathways in avian skeletal muscle during thermogenesis.About:
This article is published in FEBS Letters.The article was published on 2005-01-03. It has received 79 citations till now. The article focuses on the topics: Skeletal muscle & Cold acclimation.read more
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Journal ArticleDOI
Metabolic characteristics and oxidative damage to skeletal muscle in broiler chickens exposed to chronic heat stress.
TL;DR: It is suggested that chronic heat exposure decreases metabolic oxidation capacity in skeletal muscle of broiler chickens, possibly due to a decrease in metabolic oxidation Capacity or due to the self-propagating scavenging system, though the system was not fully activated.
Journal ArticleDOI
Acute Heat Stress Induces Oxidative Stress and Decreases Adaptation in Young White Leghorn Cockerels by Downregulation of Avian Uncoupling Protein
TL;DR: Results suggest that exposure of young cockerels to heat stress stimulates mitochondrial superoxide production, possibly via downregulation of avUCP, and can be assumed that appropriate expression ofAvUCP may alleviate overproduction of mitochondrialsuperoxide and could help birds adapt to oxidative stress resulting from acute heat stress.
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Sequential changes in superoxide production, anion carriers and substrate oxidation in skeletal muscle mitochondria of heat-stressed chickens.
TL;DR: The results suggest that overproduction of mitochondrial ROS in chicken skeletal muscle under the heat stress might result from enhanced substrate oxidation and downregulation of avUCP in a time‐dependent manner.
Journal ArticleDOI
Endothermy in birds: underlying molecular mechanisms
Isabel Walter,Frank Seebacher +1 more
TL;DR: The relationship between oxidative capacity and uncoupling indicates that there is a continuum of phenotypes that fall between the extremes of selection for increased heat production and increased aerobic activity, whereas increased cellular ATP demand is a prerequisite for increased oxidative capacity.
Journal ArticleDOI
Responses to temperature variation: integration of thermoregulation and metabolism in vertebrates.
TL;DR: Endothermic adaptive thermogenesis may result from the same regulatory pathways as ectothermic metabolic acclimation, and both could be considered as adaptive metabolic responses to temperature variation.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
Zhidan Wu,Pere Puigserver,Ulf Andersson,Chen-Yu Zhang,Guillaume Adelmant,Vamsi K. Mootha,Amy E Troy,Saverio Cinti,Bradford B. Lowell,Richard C. Scarpulla,Bruce M. Spiegelman +10 more
TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Pere Puigserver,Zhidan Wu,Cheol Won Park,Reed A. Graves,Margaret E. Wright,Bruce M. Spiegelman +5 more
TL;DR: Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.
Journal ArticleDOI
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Jiandie D. Lin,Hai Wu,Paul T. Tarr,Chen-Yu Zhang,Zhidan Wu,Olivier Boss,Laura F. Michael,Pere Puigserver,Elji Isotani,Eric N. Olson,Bradford B. Lowell,Rhonda S Bassel-Duby,Bruce M. Spiegelman +12 more
TL;DR: Using fibre-type-specific promoters, it is shown in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression.
Journal ArticleDOI
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
J. Cliff Yoon,Pere Puigserver,Guoxun Chen,Jerry Donovan,Zhidan Wu,James Rhee,Guillaume Adelmant,John M. Stafford,C. Ronald Kahn,Daryl K. Granner,Christopher B. Newgard,Bruce M. Spiegelman +11 more
TL;DR: The results implicate PGC-1 as a key modulator of hepatic gluconeogenesis and as a central target of the insulin–cAMP axis in liver.