Journal ArticleDOI
Potentiating effects of caffeine on teratogenicity of alkylating agents in mice
Takaaki Fujii,Toshio Nakatsuka +1 more
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The teratogenicity of mitomycin C was significantly potentiated by caffeine at a dose as low as 12.5 mg/kg, but similar potentiation was not observed for x-ray, MNNG, thio-TEPA, and cyclophosphamide.Abstract:
Teratogenic to subteratogenic doses of x-ray, mitomycin C, MNNG, thio-TEPA, cyclophosphamide, and chlorambucil were administered to pregnant ICR mice together with caffeine at doses of 12.5, 25, or 50 mg/kg on day 11 of gestation. Fetuses were examined for gross malformations on day 18 of gestation. The teratogenicity of mitomycin C was significantly potentiated by caffeine at a dose as low as 12.5 mg/kg. The teratogenicity of chlorambucil was also significantly potentiated by caffeine at 50 mg/kg, but similar potentiation was not observed for x-ray, MNNG, thio-TEPA, and cyclophosphamide.read more
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Teratogen update: evaluation of the reproductive and developmental risks of caffeine
TL;DR: The objectives of the present review are to summarize the findings from the various clinical and animals studies, objectively discuss the merits and/or faults inherent in the studies and establish a global reproductive risk assessment for caffeine consumption in humans during pregnancy.
Journal ArticleDOI
Effects of immunosuppressive drugs during pregnancy.
Bonnie L. Bermas,Joseph A. Hill +1 more
Journal ArticleDOI
Potential teratogenic and neurodevelopmental consequences of coffee and caffeine exposure: A review on human and animal data
Astrid Nehlig,Gérard Debry +1 more
TL;DR: Caffeine potentiates the teratogenic effect of other substances, such as tobacco, alcohol, and acts synergistically with ergotamine and propranolol to induce materno-fetal vasoconstrictions leading to malformations induced by ischemia, therefore, even though caffeine does not seem to be harmful to the human fetus when intake is moderate and spread out over the day, some associations, especially with alcohol, tobacco, and vasconstrictive or anti
Journal ArticleDOI
Effects of antiinflammatory and immunosuppressive drugs on pregnancy and fertility
References
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Journal ArticleDOI
X‐ray induced developmental abnormalities in the mouse and their use in the analysis of embryological patterns. I. External and gross visceral changes
Journal ArticleDOI
Congenital Malformations in Offspring of Mice Treated with Caffcine.
Hideo Nishimura,Kazuo Nakm +1 more
TL;DR: Pregnant mice were given single intraperitoneal injections of caffeine on different days of gestation, and malformations, predominantly in the skeletal system, were observed, with no macroscopic or microscopic changes observed in placentae of malformed young.
Journal Article
The Teratogenicity of Cyclophosphamide in Mice
TL;DR: Cyclophosphamide, administered intraperitoneally to time-dated pregnant Swiss Webster mice on gestational Days 9 through 14 in a dosage of 20 mg/kg, resulted in increased numbers of resorption and decreased growth rates in a dose-related manner but produced no discernible anomalies.
Book ChapterDOI
Cell Death and Reduced Proliferative Rate
TL;DR: It becomes necessary to know the secondary consequences of cell death in a particular organ system so that the temporal and quantitative aspects of necrosis needed to produce malformation become explainable.
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Congenital Malformations in Offspring of Mice Treated with Caffcine.
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