Journal ArticleDOI
Poultry coccidiosis: recent advancements in control measures and vaccine development
Rami A. Dalloul,Hyun S. Lillehoj +1 more
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TLDR
The current progress in understanding the host immune response to Eimeria is reviewed and current and potential strategies being developed for coccidiosis control in poultry are discussed.Abstract:
Coccidiosis is recognized as the major parasitic disease of poultry and is caused by the apicomplexan protozoan Eimeria. Coccidiosis seriously impairs the growth and feed utilization of infected animals resulting in loss of productivity. Conventional disease control strategies rely heavily on chemoprophylaxis and, to a certain extent, live vaccines. Combined, these factors inflict tremendous economic losses to the world poultry industry in excess of USD 3 billion annually. Increasing regulations and bans on the use of anticoccidial drugs coupled with the associated costs in developing new drugs and live vaccines increases the need for the development of novel approaches and alternative control strategies for coccidiosis. This paper aims to review the current progress in understanding the host immune response to Eimeria and discuss current and potential strategies being developed for coccidiosis control in poultry.read more
Citations
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In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal
Ricardo T. Gazzinelli,Maria Wysocka,Sara Hieny,Tanya Scharton-Kersten,Allen W. Cheever,Ralf Kühn,Werner Müller,Giorgio Trinchieri,Alan Sher +8 more
TL;DR: In vitro depletion experiments indicated that CD4+ lymphocytes are the major source of the latter cytokine in the spleen cell populations, and in vivo depletion with anti-CD4 Abs protected the IL-10 KO mice from parasite-induced mortality.
Journal ArticleDOI
Securing poultry production from the ever-present Eimeria challenge.
Damer P. Blake,Fiona M. Tomley +1 more
TL;DR: Some recent approaches for the production of cheaper third generation vaccines are reviewed, based on robust methods for identification of immunoprotective antigens and the use of transgenic Eimeria.
Journal ArticleDOI
Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections.
TL;DR: It is concluded that coccidiosis induces a diverse and robust primary cytokine/chemokine response, but a more subdued secondary response.
Journal ArticleDOI
Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies
H.W. Peek,Wil J.M. Landman +1 more
TL;DR: Live attenuated and non-attenuated anticoccidial vaccines have proved to be the most solid and successful coccidiosis prevention and control strategy, and despite the drawbacks associated with their production and use, their popularity is increasing.
Journal ArticleDOI
Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens.
TL;DR: A global chicken intestinal immune response is produced following experimental Eimeria infection involving multiple cytokines, chemokines, and T cell subsets, as well as changes in IEL numbers were quantified.
References
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